A novel survival model of cardioplegic arrest and cardiopulmonary bypass in rats: a methodology paper.

Journal of Cardiothoracic Surgery
Fellery de LangeG Burkhard Mackensen

Abstract

Given the growing population of cardiac surgery patients with impaired preoperative cardiac function and rapidly expanding surgical techniques, continued efforts to improve myocardial protection strategies are warranted. Prior research is mostly limited to either large animal models or ex vivo preparations. We developed a new in vivo survival model that combines administration of antegrade cardioplegia with endoaortic crossclamping during cardiopulmonary bypass (CPB) in the rat. Sprague-Dawley rats were cannulated for CPB (n = 10). With ultrasound guidance, a 3.5 mm balloon angioplasty catheter was positioned via the right common carotid artery with its tip proximal to the aortic valve. To initiate cardioplegic arrest, the balloon was inflated and cardioplegia solution injected. After 30 min of cardioplegic arrest, the balloon was deflated, ventilation resumed, and rats were weaned from CPB and recovered. To rule out any evidence of cerebral ischemia due to right carotid artery ligation, animals were neurologically tested on postoperative day 14, and their brains histologically assessed. Thirty minutes of cardioplegic arrest was successfully established in all animals. Functional assessment revealed no neurologic deficits, and ...Continue Reading

References

Jan 1, 1990·Anesthesiology·D T Mangano
Oct 1, 1995·The Annals of Thoracic Surgery·C O MurphyR A Guyton
Mar 1, 1996·The Journal of Thoracic and Cardiovascular Surgery·J H StevensB A Reitz
Oct 1, 1996·The Annals of Thoracic Surgery·L TorraccaR Ferrari
Dec 1, 1996·The Annals of Thoracic Surgery·F E SchmidtR A Guyton
Dec 10, 1999·The Annals of Thoracic Surgery·J L Park, B R Lucchesi
Jan 5, 2000·Heart·R Prêtre, M I Turina
Mar 15, 2000·Journal of the American College of Cardiology·K P AlexanderE D Peterson
Oct 7, 2000·Stroke; a Journal of Cerebral Circulation·T OmaeM Fisher
Feb 24, 2001·Perfusion·H P GrocottD S Warner
Jun 23, 2001·Perfusion·O FabreJ N Fabiani
Jul 12, 2001·Circulation·M J DavidsonC A Milano
Jun 14, 2002·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·J M JonesC A Milano
Jun 28, 2003·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Uwe M FischerUwe Mehlhorn
Oct 18, 2003·Anesthesiology Clinics of North America·Stanton K Shernan
Mar 6, 2004·The Journal of Thoracic and Cardiovascular Surgery·Geoffrey P Dobson, Michael W Jones
Feb 1, 2005·The Journal of Surgical Research·Guo-Hua DongHua Jing
Mar 5, 2005·The Journal of Thoracic and Cardiovascular Surgery·Joel S CorveraJakob Vinten-Johansen
Feb 21, 2006·The Annals of Thoracic Surgery·E Marty KnottRobert T Mallet
Mar 1, 2006·Life Sciences·Jan M DielemanCor J Kalkman
Apr 4, 2006·The Journal of Thoracic and Cardiovascular Surgery·Bettina JungwirthGeorg Nollert

❮ Previous
Next ❯

Citations

Mar 15, 2011·The Journal of Thoracic and Cardiovascular Surgery·Tom WaterburyRobert Saeid Farivar
May 8, 2015·BMJ Open·Miklos D KertaiUNKNOWN Duke Perioperative Genetics and Safety Outcomes (PEGASUS) Investigative Team
Mar 26, 2010·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Taketoshi MaedaRyuji Tominaga
Apr 17, 2012·The International Journal of Artificial Organs·Marion BernerSarah L Longnus
Apr 2, 2017·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Michele M SalzmanMatthias L Riess
May 19, 2010·Seminars in Cardiothoracic and Vascular Anesthesia·Bettina Jungwirth, Fellery de Lange
Feb 27, 2013·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Heike SchnoeringJaime F Vazquez-Jimenez
Oct 5, 2017·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Nodir MadrahimovAxel Haverich
Jan 10, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Nick J KoningChrista Boer
Nov 7, 2018·The Journal of Thoracic and Cardiovascular Surgery·Mingyue LiuBingyang Ji

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Related Papers

ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Giovanni Domenico CresceGiuseppe Faggian
Interactive Cardiovascular and Thoracic Surgery
Zhonghua ShenHua Jing
© 2022 Meta ULC. All rights reserved