A novel synthesis of 3-aryl coumarins and evaluation of their antioxidant and lipoxygenase inhibitory activity

Bioorganic & Medicinal Chemistry Letters
Marina RoussakiAnastasia Detsi

Abstract

A series of coumarin analogues bearing a substituted phenyl ring on position 3 were synthesized via a novel methodology, through an intermolecular condensation reaction of 2-hydroxyacetophenones and 2-hydroxybenzaldehyde, with imidazolyl phenylacetic acid active intermediates. The in vitro antioxidant activity of the synthesized compounds was evaluated using two different antioxidant assays (radical scavenging ability of DPPH stable free radical and inhibition of lipid peroxidation induced by the thermal free radical AAPH). Moreover, the ability of the compounds to inhibit soybean lipoxygenase was determined as an indication of potential anti-inflammatory activity.

References

May 20, 2003·Journal of Enzyme Inhibition and Medicinal Chemistry·Christos Kontogiorgis, Dimitra Hadjipavlou-Litina
Mar 31, 2006·Journal of Enzyme Inhibition and Medicinal Chemistry·Christos A KontogiorgisDimitra J Hadjipavlou-Litina

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Citations

Sep 20, 2011·Journal of Medicinal Chemistry·Maria J MatosDolores Viña
Apr 5, 2012·The Journal of Pharmacy and Pharmacology·Maria João MatosAntonella Fais
Dec 12, 2012·The Journal of Pharmacy and Pharmacology·Maria João MatosEugenio Uriarte
Oct 15, 2013·The Journal of Pharmacy and Pharmacology·Maria João MatosKarl-Norbert Klotz
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Nov 19, 2015·Acta Pharmaceutica Sinica. B·Radha Krishan AroraGulshan Bansal
Jul 3, 2015·Scientific Reports·Ahmed A Al-AmieryAbu Bakar Mohamad
Aug 4, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dionisio OlmedoArturo San Feliciano
May 12, 2018·Molecular Nutrition & Food Research·Jing-Jing Zhu, Jian-Guo Jiang
Jan 5, 2018·Anti-cancer Agents in Medicinal Chemistry·Saleem FarooqS Koul
Sep 13, 2018·Medicinal Chemistry·Saleem FarooqSurrinder Koul
Jan 17, 2020·Drug Development Research·Eleni KavetsouAnastasia Detsi
Dec 2, 2019·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Lucinéia Reuse AlbieroYara Maria Lucisano-Valim
Jun 3, 2021·Medicines·Olubukola Sinbad OlorunnisolaOlumide Samuel Fadahunsi
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ioanna KostopoulouAnastasia Detsi
Dec 19, 2019·Medicinal Chemistry·Nataša PerinMarijana Hranjec

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