A novel synthetic chemistry approach to linkage-specific ubiquitin conjugation

Organic & Biomolecular Chemistry
Rachel E MorganStephen Caddick

Abstract

Ubiquitination is of great importance as the post-translational modification of proteins with ubiquitin, or ubiquitin chains, facilitates a number of vital cellular processes. Herein we present a facile method of preparing various ubiquitin conjugates under mild conditions using michael acceptors based on dibromo-maleimides and dibromo-pyridazinediones.

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Citations

Apr 27, 2016·Chembiochem : a European Journal of Chemical Biology·Kun YangZhihao Zhuang
May 31, 2017·International Journal of Molecular Sciences·Daichi MorimotoMasahiro Shirakawa
Aug 11, 2018·Chemistry : a European Journal·João M J M RavascoPedro M P Gois
Oct 16, 2018·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Seiji Sakamoto, Itaru Hamachi
May 22, 2016·The Biochemical Journal·Mathew Stanley, Satpal Virdee
Apr 28, 2020·Journal of the American Chemical Society·Alice L BaumannChristian P R Hackenberger
Dec 13, 2017·Bioconjugate Chemistry·Bikram Keshari AgrawallaTanja Weil

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Methods Mentioned

BETA
ubiquitination

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