A novel technique for detecting antibiotic-resistant typhoid from rapid diagnostic tests

Journal of Clinical Microbiology
Caoimhe Nic FhogartaighPaul N Newton

Abstract

Fluoroquinolone-resistant typhoid is increasing. An antigen-detecting rapid diagnostic test (RDT) can rapidly diagnose typhoid from blood cultures. A simple, inexpensive molecular technique performed with DNA from positive RDTs accurately identified gyrA mutations consistent with phenotypic susceptibility testing results. Field diagnosis combined with centralized molecular resistance testing could improve typhoid management and surveillance in low-resource settings.

References

Feb 7, 2001·Journal of Clinical Microbiology·W A Al-Soud, P Rådström
Jul 1, 2006·Transactions of the Royal Society of Tropical Medicine and Hygiene·Stuart D BlacksellPaul N Newton
Jul 10, 2007·Transactions of the Royal Society of Tropical Medicine and Hygiene·Sharon J Peacock, Paul N Newton
Jan 24, 2008·Antimicrobial Agents and Chemotherapy·John A CrumpUNKNOWN Emerging Infections Program FoodNet and NARMS Working Groups
Apr 29, 2008·Bulletin of the World Health Organization·R Leon OchiaiUNKNOWN Domi Typhoid Study Group
Apr 21, 2010·Annals of Clinical Microbiology and Antimicrobials·Liqing Zhou, Andrew J Pollard
Jul 4, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Romney M HumphriesJanet A Hindler
Nov 6, 2012·Transactions of the Royal Society of Tropical Medicine and Hygiene·Kate EmaryChristopher M Parry
Dec 25, 2013·The American Journal of Tropical Medicine and Hygiene·Pieter W SmitPaul N Newton

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Citations

Jul 21, 2016·Emerging Infectious Diseases·Sabine DittrichPaul N Newton
May 10, 2016·PLoS Neglected Tropical Diseases·Manivanh VongsouvathAudrey Dubot-Pérès
Feb 18, 2016·The American Journal of Tropical Medicine and Hygiene·Sabine DittrichPaul N Newton
Jan 29, 2020·The American Journal of Tropical Medicine and Hygiene·Tamalee RobertsPaul N Newton
Aug 15, 2021·The Lancet. Planetary Health·Audrey Dubot-PérèsPaul N Newton

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Methods Mentioned

BETA
PCR

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