A novel ternary ligand system useful for preparation of cationic (99m)Tc-diazenido complexes and (99m)Tc-labeling of small biomolecules

Bioconjugate Chemistry
Young-Seung KimShuang Liu

Abstract

This report describes a novel ternary ligand system composed of a phenylhydrazine, a crown ether-containing dithiocarbamate (DTC), and a PNP-type bisphosphine (PNP). The combination of three different ligands with (99m)Tc results in cationic (99m)Tc-diazenido complexes, [(99m)Tc(NNAr)(DTC)(PNP)]+, with potential radiopharmaceuticals for heart imaging. Synthesis of cationic (99m)Tc-diazenido complexes can be accomplished in two steps. For example, the reaction of phenylhydrazine with (99m)TcO4- at 100 degrees C in the presence of excess stannous chloride and 1,2-diaminopropane-N,N,N',N'-tetraacetic acid (PDTA) results in the [(99m)Tc(NNPh)(PDTA)n] intermediate, which then reacts with sodium N-(dithiocarbamato)-2-aminomethyl-15-Crown-5 (L4) and N,N-bis[2-(bis(3-ethoxypropyl)phosphino)ethyl]ethoxyethylamine (PNP6) at 100 degrees C for 15 min to give the complex, [(99m)Tc(NNPh)(L4)(PNP6)]+ in high yield (>90%). Cationic complexes [(99m)Tc(NNPh)(DTC)(PNP)]+ are stable for > or = 6 h. Their composition was determined to be 1:1:1:1 for Tc:NNPh:DTC:PNP using the mixed-ligand experiments on the tracer ((99m)Tc) level and was further confirmed by the ESI-MS spectral data of a model compound [Re(NNPh)(L4)(L6)]+. It was found that both DTC...Continue Reading

References

Jan 1, 1984·International Journal of Nuclear Medicine and Biology·A G JonesA I Kassis
Jan 1, 1993·European Journal of Nuclear Medicine·P CraneC Orlandi
Nov 5, 1997·Bioconjugate Chemistry·S LiuJ A Barrett
Aug 7, 1999·European Journal of Nuclear Medicine·C Decristoforo, S J Mather
Sep 3, 1999·Nuclear Medicine and Biology·E C LisicE Deutsch
Sep 30, 1999·Bioconjugate Chemistry·D S EdwardsB A Ewels
Jan 19, 2000·Bioconjugate Chemistry·S LiuD S Edwards
Feb 24, 2001·Nuclear Medicine Communications·A H BrouwersF H Corstens
Feb 18, 2003·Inorganic Chemistry·Andrew R CowleyPaul S Donnelly

❮ Previous
Next ❯

Citations

May 12, 2010·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Lihong BuXiaoyuan Chen
Mar 17, 2009·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Young-Seung KimShuang Liu
Aug 5, 2008·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Young-Seung KimShuang Liu
Aug 1, 2012·Radiochimica acta·Valerie CarrollSilvia S Jurisson
Dec 13, 2006·Dalton Transactions : an International Journal of Inorganic Chemistry·Andrew R CowleySusan J Ross
Apr 2, 2013·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Cristina BolzatiNicola Antonio Colabufo
Aug 7, 2013·Clinical Nuclear Medicine·Shi GaoQingjie Ma
Mar 14, 2007·Dalton Transactions : an International Journal of Inorganic Chemistry·Shuang Liu
Apr 22, 2009·Dalton Transactions : an International Journal of Inorganic Chemistry·Leonor MariaIsabel Santos

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.