A novel testing model for opportunistic screening of pre-diabetes and diabetes among U.S. adults

PloS One
Yurong ZhangLiwei Chen

Abstract

The study aim was to evaluate the performance of a novel simultaneous testing model, based on the Finnish Diabetes Risk Score (FINDRISC) and HbA1c, in detecting undiagnosed diabetes and pre-diabetes in Americans. This cross-sectional analysis included 3,886 men and women (≥ 20 years) without known diabetes from the U.S. National Health and Nutrition Examination Survey (NHANES) 2005-2010. The FINDRISC was developed based on eight variables (age, BMI, waist circumference, use of antihypertensive drug, history of high blood glucose, family history of diabetes, daily physical activity and fruit & vegetable intake). The sensitivity, specificity, and the receiver operating characteristic (ROC) curve of the testing model were calculated for undiagnosed diabetes and pre-diabetes, determined by oral glucose tolerance test (OGTT). The prevalence of undiagnosed diabetes was 7.0% and 43.1% for pre-diabetes (27.7% for isolated impaired fasting glucose (IFG), 5.1% for impaired glucose tolerance (IGT), and 10.3% for having both IFG and IGT). The sensitivity and specificity of using the HbA1c alone was 24.2% and 99.6% for diabetes (cutoff of ≥6.5%), and 35.2% and 86.4% for pre-diabetes (cutoff of ≥5.7%). The sensitivity and specificity of usin...Continue Reading

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Citations

Oct 18, 2018·Expert Review of Endocrinology & Metabolism·Donald A Williamson
Oct 6, 2018·AIDS·Karla I GalavizMohammed K Ali
May 14, 2019·Expert Opinion on Biological Therapy·Sahar MohsinErnest A Adeghate
Sep 14, 2019·F1000Research·Bernard Effah NyarkoAlessandro Crimi
Jan 17, 2020·Diabetes/metabolism Research and Reviews·Avivit CahnItamar Raz
Sep 5, 2020·Clinical Medicine Insights. Endocrinology and Diabetes·Mohammed AbusaibAbbas Mansour
Mar 9, 2021·AIDS Research and Human Retroviruses·Karla I GalavizTodd T Brown

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Methods Mentioned

BETA
blood draws
blood draw

Software Mentioned

FINDRISC
SAS

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