A novel theranostic activity-based probe targeting kallikrein 7 for the diagnosis and treatment of skin diseases.

Chemical Communications : Chem Comm
Evangelos BisyrisGeorgia Sotiropoulou

Abstract

We applied a new in silico approach for using protease-substrate motifs to design a kallikrein 7 (KLK7)-specific phosphonate activity-based probe (ABP) to quantify the active KLK7 in situ. Epidermal application of the ABP-inhibitor on Spink5-/-Klk5-/- mice, a Netherton syndrome model, reversed disease hallmarks, providing preclinical proof-of-concept for using ABPs as theranostics.

References

Sep 7, 2001·Nature Genetics·A J WalleyW O Cookson
Feb 26, 2010·Biological Chemistry·Georgia Sotiropoulou, Georgios Pampalakis
Apr 24, 2012·The Journal of Allergy and Clinical Immunology·Shin MorizaneKeiji Iwatsuki
Oct 24, 2012·Trends in Pharmacological Sciences·Georgia Sotiropoulou, Georgios Pampalakis
Sep 22, 2015·PLoS Genetics·Laetitia FurioAlain Hovnanian
Nov 4, 2016·Nature Chemical Biology·Jürgen MaibaumKaren Anderson
Jan 18, 2017·PLoS Genetics·Petr KasparekRadislav Sedlacek
Mar 4, 2017·Chemical Communications : Chem Comm·G PampalakisG Sotiropoulou
Jun 14, 2017·Medicinal Research Reviews·Nicolas MasurierVincent Lisowski
May 23, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Eleni ZingkouGeorgia Sotiropoulou

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Citations

Jul 27, 2021·Organic & Biomolecular Chemistry·Evangelos BisyrisGeorgia Sotiropoulou

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