A novel thermoresponsive hydrogel with ion-recognition property through supramolecular host-guest complexation

The Journal of Physical Chemistry. B
Xiao-Jie JuYoung Moo Lee

Abstract

A novel thermoresponsive hydrogel with ion-recognition property was prepared via free-radical cross-linking copolymerization of N-isopropylacrylamide (NIPAM) with benzo-18-crown-6-acrylamide (BCAm) as host receptor. Both chemical structures and stimuli-sensitive properties of the prepared poly(N-isopropylacrylamide-co-benzo-18-crown-6-acrylamide) P(NIPAM-co-BCAm) hydrogel were characterized. The smart hydrogel could respond to both temperature and ion stimuli. When the crown ether units captured Ba2+ and formed stable BCAm/Ba2+ host-guest complexes, the lower critical solution temperature (LCST) of the hydrogel increased due to the repulsion among charged BCAm/Ba2+ complex groups and osmotic pressure within the hydrogel. Whereas crown ethers captured Cs+, the LCST shifted to a lower temperature because of the formation of 2:1 sandwich complexes. Unexpectedly, the LCST of the cross-linked P(NIPAM-co-BCAm) hydrogel in K+ solution did not shift to a higher temperature, which was definitely different from the previously reported linear P(NIPAM-co-BCAm) copolymer in K+ solution. The results of this work provide valuable information for development of dual thermo- and ion-responsive hydrogels which have potential applications in drug...Continue Reading

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Citations

Oct 21, 2009·Accounts of Chemical Research·Hans-Jörg Schneider, Robert M Strongin
Oct 20, 2010·International Journal of Nanomedicine·Xin-Cai Xiao, Zong-Guo Hong
Apr 23, 2013·Chemistry : a European Journal·Kamaljit SinghHiroshi Tsukube
Jun 29, 2010·Journal of Colloid and Interface Science·Eulogio Orozco-GuareñoSergio Gomez-Salazar
Jun 23, 2009·The Journal of Physical Chemistry. B·Yanlei SuZhongyi Jiang

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