A novel three-dimensional magnetic particle imaging system based on the frequency mixing for the point-of-care diagnostics.

Scientific Reports
Seung-Min ChoiIn So Kweon

Abstract

The magnetic particle imaging (MPI) is a technology that can image the concentrations of the superparamagnetic iron oxide nanoparticles (SPIONs) which can be used in biomedical diagnostics and therapeutics as non-radioactive tracers. We proposed a point-of-care testing MPI system (PoCT-MPI) that can be used for preclinical use for imaging small rodents (mice) injected with SPIONs not only in laboratories, but also at emergency sites far from laboratories. In particular, we applied a frequency mixing magnetic detection method to the PoCT-MPI, and proposed a hybrid field free line generator to reduce the power consumption, size and weight of the system. The PoCT-MPI is [Formula: see text] in size and weighs less than 100 kg. It can image a three-dimensional distribution of SPIONs injected into a biosample with less than 120 Wh of power consumption. Its detection limit is [Formula: see text], 10 mg/mL, [Formula: see text] (Fe).

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Citations

Nov 17, 2020·Current Opinion in Psychiatry·Nady BraidyPerminder S Sachdev

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Methods Mentioned

BETA
PCR
X-ray
chips

Software Mentioned

Chemicell
PoCT
FMMD
Matlab
MPI

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