PMID: 9169966Jun 1, 1997Paper

A novel tool to quantify physical activities: ambulatory accelerometry in psychopharmacology

Journal of Clinical Psychopharmacology
J H TulenA J Man in 't Veld

Abstract

Accelerometry by means of body-mounted piezoresistive sensors was evaluated as a new method to quantify physical activities (body posture and physical and locomotor activity) in relation to the sedative and cardiovascular effects of benzodiazepines, in an ambulatory study. In a double-blind, randomized, crossover study, 12 healthy men received either an oral dose of 2 mg lorazepam, 0.5 mg alprazolam, 1 mg alprazolam, or a placebo on 4 different days. By means of a portable digital recorder, each day 4 hours of continuous measurements of accelerometer signals and heart rate were performed in a living room in the hospital. Changes in subjective sleepiness were assessed at the beginning, halfway, and at the end of the recording period. A separate validation study of the ambulatory environment was performed in three subjects, in which computer classification of activities based on accelerometry was compared with visual evaluation of simultaneously recorded videotapes. In our validation study, comparison of the computer classification with visual analysis based on videotapes revealed an overall agreement for spontaneous and standardized activities of 88% and 96%, respectively. In our pharmacological study, the subjects spent more ti...Continue Reading

References

Sep 1, 1988·Clinical Pharmacology and Therapeutics·D J GreenblattR I Shader
Jul 1, 1973·Psychophysiology·E HoddesW C Dement
Apr 1, 1994·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·T RohrerH Lehnert

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Citations

Dec 11, 1999·Schizophrenia Research·K TuiskuR Rimon
Oct 10, 2001·Behavior Research Methods, Instruments, & Computers : a Journal of the Psychonomic Society, Inc·J B BussmannH J Stam
Oct 10, 2001·Behavior Research Methods, Instruments, & Computers : a Journal of the Psychonomic Society, Inc·J H TulenB J van de Wetering
Mar 11, 2005·Archives of Physical Medicine and Rehabilitation·Arturo Vega-González, Malcolm H Granat
Apr 15, 2004·Archives of Physical Medicine and Rehabilitation·Fabiënne C SchasfoortHenk J Stam
Apr 27, 2004·Journal of Hypertension·Marinel CavelaarsAnton H van den Meiracker
Nov 7, 2003·The Journal of Clinical Endocrinology and Metabolism·Katia Juliane HarzChristian Roth
Oct 3, 2002·Journal of Hypertension·Marinel CavelaarsAnton H van den Meiracker

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