A novel tumor-associated antigen expressed in human uterine and ovarian carcinomas

Cancer
K SonodaT Watanabe

Abstract

A large number of monoclonal antibodies (MoAbs) against human tumor cells have been generated and it has been shown that these MoAbs are useful tools in the diagnosis and treatment of cancer patients, as well as in the basic investigation of the oncogenesis and characterization of cancer cells. The 22-1-1 MoAb was established by cell fusion between mouse myeloma cells and spleen cells derived from mice immunized with the human uterine cervical adenocarcinoma cell line, SiSo. The tissue distribution and biologic characteristics of the 22-1-1 antigen (Ag) were examined. The 22-1-1 Ag was distinct from the known tumor-associated antigens such as YH 206, GA 733, CA 125, carcinoembryonic antigen, and sialyl Le(x) molecules in an expression pattern in human tumor cell lines. An immunohistochemical study revealed that 22-1-1 Ag was expressed in 87.5% of uterine cervical adenocarcinomas, 66% of uterine endometrial adenocarcinomas, and 58.8% of ovarian carcinomas. Moreover, 22-1-1 Ag was detected in 87.7% of uterine cervical squamous cell carcinomas; however, it was not detected in 87.7% of uterine cervical or ovarian tissues, except in uterine endometrial glands, in which its expression was observed at low levels. The 22-1-1 Ag was sec...Continue Reading

References

Nov 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·D Solter, B B Knowles
Nov 1, 1990·Japanese Journal of Cancer Research : Gann·T SagaM Sawada
Jan 1, 1990·Cancer·A LeminenE Vesterinen
Jan 1, 1990·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·C PoropatichS G Silverberg
Dec 1, 1989·Journal of Neurosurgery·A NandaD Herlyn
Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·A J LinnenbachH Koprowski
Jan 1, 1987·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·A ThorF Gorstein
Jan 1, 1986·Journal of Cancer Research and Clinical Oncology·M DietelL Hoffmann
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·R F Irie, D L Morton
Sep 11, 1986·The New England Journal of Medicine·J A CarrasquilloR K Oldham
Feb 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·A N HoughtonL J Old
Jan 26, 1980·Lancet·J R van Nagell, J R Goldenberg
Jun 1, 1981·American Journal of Clinical Pathology·S M HsuH Fanger
Jan 1, 1983·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·S E KabawatR B Colvin
May 1, 1984·British Journal of Obstetrics and Gynaecology·R S JhaD V Coleman
Oct 1, 1984·British Journal of Obstetrics and Gynaecology·A M Ferguson, H Fox
Mar 1, 1982·The American Journal of Surgical Pathology·C CohenL R Budgeon
Jun 1, 1982·Gynecologic Oncology·H K Tamimi, D C Figge

❮ Previous
Next ❯

Citations

Mar 29, 2000·Biochemical and Biophysical Research Communications·M Muramatsu, S Inoue
Jun 30, 2000·Biochemical and Biophysical Research Communications·K IkedaS Inoue
Jul 12, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·T AokiM Makuuchi
Jun 3, 2014·Journal of Translational Medicine·Hideaki TanakaSeiji Nakamura
Sep 30, 2003·Journal of Clinical Pathology·K LeelawatV Leardkamolkarn
Jan 21, 2006·Cancer Research·Madhumita ChatterjeeMichael A Tainsky
Mar 11, 2010·BMC Immunology·Magdalena Dutsch-WicherekWojciech Jóźwicki
Jan 1, 2010·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Magdalena Dutsch-WicherekRomana Tomaszewska
Aug 2, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Stamatios TheocharisXavier Sastre-Garau
Jul 16, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Kazuya OkadaTakeshi Watanabe
Feb 13, 2015·International Journal of Molecular Sciences·Wojciech JóźwickiAndrzej T Slominski
Jul 3, 2007·Journal of Reproductive Immunology·E TskitishviliK Shimoya
Aug 4, 2004·Liver International : Official Journal of the International Association for the Study of the Liver·Munechika EnjojiHajime Nawata
Apr 9, 2005·European Journal of Haematology·Youko SuehiroJunji Nishimura
Jul 29, 2005·Journal of Gastroenterology and Hepatology·Munechika EnjojiMakoto Nakamuta
Apr 22, 2005·Journal of Surgical Oncology·Hiroyuki KatoHiroyuki Kuwano
Mar 26, 2003·Clinical and Experimental Dermatology·M EnjojiH Nawata
Mar 16, 2004·Cancer Science·Yuichi NakamuraMasaharu Nishimura
Feb 12, 2009·International Journal of Urology : Official Journal of the Japanese Urological Association·Tetsuya FujimuraSatoshi Inoue
Oct 10, 2007·American Journal of Reproductive Immunology : AJRI·Ekaterine TskitishviliKoichiro Shimoya
Apr 6, 2006·Liver International : Official Journal of the International Association for the Study of the Liver·Munechika EnjojiMakoto Nakamuta
Jun 10, 2006·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·T ToyoshimaK Shirasuna
Nov 26, 2008·International Journal of Cancer. Journal International Du Cancer·Jinpei KumagaiSatoshi Inoue
May 21, 2010·American Journal of Reproductive Immunology : AJRI·Ekaterine TskitishviliTadashi Kimura
Dec 18, 2009·American Journal of Reproductive Immunology : AJRI·Ekaterine TskitishviliKoichiro Shimoya
Jan 21, 2010·American Journal of Reproductive Immunology : AJRI·Magdalena Dutsch-Wicherek
Oct 6, 2004·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·M EnjojiT Watanabe
Jul 18, 2006·Gynecologic Oncology·Kenzo SonodaHitoo Nakano
Apr 26, 2006·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Hasan OzkanSahin Coban
Aug 23, 2005·Gynecologic Oncology·Kenzo SonodaHitoo Nakano
Jun 11, 2002·Biochemical and Biophysical Research Communications·Joel RousseauBenoit Guérette
Mar 22, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Su-xia HanQing Zhu
Jul 9, 2004·The Journal of Veterinary Medical Science·Yasuhiko OkamuraYasuho Taura
Sep 3, 2003·The Journal of Veterinary Medical Science·Yasuhiko OkamuraYasuho Taura
Jun 29, 2010·American Journal of Obstetrics and Gynecology·Ekaterine TskitishviliTadashi Kimura
Jan 10, 2013·Otolaryngologia polska. The Polish otolaryngology·Magdalena Dutsch-WicherekHenryk Kaźmierczak
May 7, 2002·International Journal of Cancer. Journal International Du Cancer·Kei HiraokaHiroyuki Katoh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.