A novel tumor suppressor ZBTB1 regulates tamoxifen resistance and aerobic glycolysis through suppressing HER2 expression in breast cancer.

The Journal of Biological Chemistry
Panhong ZhangJiajun Cui

Abstract

Transcriptional repressor zinc finger and BTB domain containing 1 (ZBTB1) is required for DNA repair. Because DNA repair defects often underlie genome instability and tumorigenesis, we determined to study the role of ZBTB1 in cancer. In this study, we found that ZBTB1 is down-regulated in breast cancer and this down-regulation is associated with poor outcome of breast cancer patients. ZBTB1 suppresses breast cancer cell proliferation and tumor growth. The majority of breast cancers are estrogen receptor (ER) positive and selective estrogen receptor modulators such as tamoxifen have been widely used in the treatment of these patients. Unfortunately, many patients develop resistance to endocrine therapy. Tamoxifen-resistant cancer cells often exhibit higher HER2 expression and an increase of glycolysis. Our data revealed that ZBTB1 plays a critical role in tamoxifen resistance in vitro and in vivo To see if ZBTB1 regulates HER2 expression, we tested the recruitments of ZBTB1 on HER2 regulatory sequences. We observed that over-expressed ZBTB1 occupies the estrogen receptor α (ERα)-binding site of the HER2 intron in tamoxifen-resistant cells, suppressing tamoxifen-induced transcription. In an effort to identify potential microRNAs ...Continue Reading

References

Nov 7, 1998·Molecular and Cellular Endocrinology·C M KlingeR Hilf
Feb 15, 2001·The New England Journal of Medicine·M Clemons, P Goss
Jul 14, 2001·Nucleic Acids Research·C M Klinge
Mar 30, 2002·Science·Yongfeng Shang, Myles Brown
Feb 14, 2003·The New England Journal of Medicine·B Lawrence Riggs, Lynn C Hartmann
Mar 6, 2003·Journal of the National Cancer Institute·C Kent OsborneRachel Schiff
Mar 15, 2003·Nature Reviews. Cancer·Simak Ali, R Charles Coombes
Jun 17, 2004·Journal of the National Cancer Institute·Jiang ShouRachel Schiff
Jan 22, 2005·Nature·Takahiro MaedaPier Paolo Pandolfi
Sep 26, 2006·Trends in Cell Biology·Kevin F Kelly, Juliet M Daniel
Mar 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tove KirkegaardJohn M S Bartlett
Aug 28, 2007·Nature Reviews. Cancer·Kelly A Green, Jason S Carroll
Sep 3, 2010·Cellular and Molecular Life Sciences : CMLS·Jiajun CuiHongbin Song
Oct 5, 2010·Annual Review of Medicine·C Kent Osborne, Rachel Schiff
Jul 23, 2011·Nature Reviews. Cancer·Christoforos Thomas, Jan-Åke Gustafsson
Sep 6, 2011·Endocrinology and Metabolism Clinics of North America·Doris Germain
Sep 17, 2011·Nature Reviews. Drug Discovery·Stefan NilssonJan-Åke Gustafsson
Dec 28, 2011·The Journal of Experimental Medicine·Owen M SiggsBruce Beutler
Sep 6, 2012·Endocrine Reviews·Bramanandam ManavathiRakesh Kumar
Apr 13, 2013·Nucleic Acids Research·Loredana PellegrinoLeandro Castellano
Jul 13, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xin CaoDamian Kovalovsky
Mar 31, 2017·Proceedings of the National Academy of Sciences of the United States of America·Liang XuH Phillip Koeffler
Apr 4, 2017·Cancer Science·Toshimitsu OhashiYatsuji Ito
Jul 22, 2017·Neoplasia : an International Journal for Oncology Research·Darshan S ChandrashekarSooryanarayana Varambally
Jun 10, 2018·Journal of Cellular and Molecular Medicine·Xin CaoZhong-Ren Ma
Aug 16, 2018·Nature Reviews. Molecular Cell Biology·Luca F R Gebert, Ian J MacRae
Sep 18, 2018·Cancer Letters·Daoshan ZhengZhaoyu Li
May 24, 2019·Cancer Letters·Angélica Santiago-GómezRobert B Clarke

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Citations

Jul 3, 2021·Cancers·Ryan W Holloway, Paola A Marignani
Jul 28, 2021·Journal of Cellular and Molecular Medicine·Ming-Yang ChengChun-Feng Wang

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