PMID: 6403866Mar 17, 1983Paper

A novel type of aberrant recombination in immunoglobulin genes and its implications for V-J joining mechanism

Nature
J Höchtl, H G Zachau

Abstract

Functional kappa light chain genes are formed during B-lymphocyte differentiation by the joining of initially separate V and J gene segments. It has been suggested that the intervening DNA is deleted, however the recent reports of what appear to be the reciprocal products of V and J recombination (back-to-back conserved V and J flanking sequences, called f-fragments) in DNA from mature lymphocytes make a simple deletion model unlikely. An alternative scheme involving unequal sister chromatid exchange has been proposed, supported by the evidence that the f-fragments seem to have segregated from the chromosome carrying the reciprocal complete kappa light chain gene (this and other schemes are briefly reviewed in ref. 8). We report here the analysis of a mouse myeloma (MOPC 41), in which a productive (kappa+) and a non-productive (kappa-) rearrangement has occured, which may help to clarify the mechanism of V-J joining. The aberrant rearrangement has led to the joining of a J1 gene segment to a sequence unrelated to any V gene (L10), and which in the germ line is flanked by a sequence resembling a V region recombination signal sequence. In this case no segregation of the reciprocal recombination products (kappa-41 and f41), which ...Continue Reading

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Citations

Jan 1, 1989·Somatic Cell and Molecular Genetics·P Dewyse, W E Bradley
Apr 1, 1994·Molecular Biotechnology·R W Briddon, P G Markham
Jul 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·R M Feddersen, B G Van Ness
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