A novel type of matrix for surface-assisted laser desorption-ionization mass spectrometric detection of biomolecules using metal-organic frameworks

Analytica Chimica Acta
Chien-Ping FuHsi-Ya Huang

Abstract

A 3D metal-organic framework (MOF) nanomaterial as matrix for surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) and tandem mass spectrometry (MS/MS) was developed for the analysis of complex biomolecules. Unlike other nanoparticle matrices, this MOF nanomaterial does not need chemical modification prior to use. An exceptional signal reproducibility as well as very low background interferences in analyzing mono-/di-saccharides, peptides and complex starch digests demonstrate its high potential for biomolecule assays, especially for small molecules.

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Citations

Nov 11, 2017·Scientific Reports·Xi LuoYuzuru Takamura
Jan 27, 2019·Analytical and Bioanalytical Chemistry·Adeela SaeedMuhammad Najam-Ul-Haq
Nov 12, 2020·Mass Spectrometry Reviews·Wendy H MüllerGauthier Eppe

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