PMID: 8604312Feb 15, 1996Paper

A novel type of retinoic acid response element in the second intron of the mouse H2Kb gene is activated by the RAR/RXR heterodimer

Nucleic Acids Research
Petr Jansa, J Forejt

Abstract

We have identified and characterized a novel retinoic acid (RA) response element (Hi-RARE) in the second intron of the mouse major histocompatibility H2Kb gene. The Hi-RARE sequence is conserved in all mouse classical and Q class 1 genes, in MHC class 1 genes of the rat, Rhesus macaque, cat and in the vast majority of human classical and non-classical class 1 genes. The Hi-RARE sequence lies within a regulatory element responsible for constitutive expression of a 5' enhancerless H2Kb gene in the Ltk-fibroblasts. Hi-RARE consists of two inverted palindromic RARE consensus sites (5'-PuGGTCA-3') separated by an 8 nt spacer. Mutational analysis revealed that both inverted palindromic hexanucleotide motifs are indispensable functional sites for the 9-cis RA response. The Hi-RARE sequence confers 9-cis RA inducibility to a heterologous promoter. The inducibility is further augmented in embryonal carcinoma cells by the expression of recombinant retinoic acid receptors (PARs) and the retinoid X receptors (RXRs). In vitro, the recombinant RAR/RXR heterodimer creates DNA-protein complex with the Hi-RARE sequence. Treatment of P19 embryonal carcinoma cells with 9C-RA induces the Hi-RARE binding activity of nuclear proteins that proved to ...Continue Reading

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Citations

Mar 26, 2004·Insect Biochemistry and Molecular Biology·Laisel MartinezRene J Herrera
May 19, 2000·Cytokine & Growth Factor Reviews·P McCaffery, U C Dräger
Aug 20, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Jirí HatinaJosef Reischig
Aug 22, 2008·Seminars in Immunology·Claire GordyYou-Wen He
Jul 4, 2006·Journal of Cellular Biochemistry·Marc A ThomasJacqueline M Bentel
Apr 27, 2005·Biochemical and Biophysical Research Communications·Shun-Yuan JiangTsu-Chung Chang
Aug 1, 1997·Cellular Immunology·N SidellS Thierfelder
Jun 4, 2021·Molecular and Cellular Endocrinology·Mohammed Taouis, Yacir Benomar

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