A novel waterborne polyurethane with biodegradability and high flexibility for 3D printing.

Biofabrication
Zhaoxuan FengHaiyue Jiang

Abstract

Three-dimensional (3D) printing provides a new approach of fabricating implantable products because it permits a flexible manner to extrude complex and customized shapes of the tissue scaffolds. Compared with other printable biomaterials, the polyurethane elastomer has several merits, including excellent mechanical properties and good biocompatibility. However, some intrinsic behavior, especially its high melting point and slow rate of degradation, hampered its application in 3D printed tissue engineering. Herein, we developed a 3D printable amino acid modified biodegradable waterborne polyurethane (WBPU) using a water-based green chemistry process. The flexibility of this material endows better compliance with tissue during implantation and prevents high modulus transplants from scratching surrounding tissues. The histocompatibility experiments show that the WBPU induces no apparent acute rejection or inflammation in vivo. We successfully fabricated a highly flexible WBPU scaffold by deposition 3D printing technology at a low temperature (50°C ~ 70 °C), and the printed products could support the adhesion and proliferation of chondrocytes and fibroblasts. The printed blocks possessed controllable degradability due to the differ...Continue Reading

References

May 23, 2008·International Journal of Biological Macromolecules·Khalid Mahmood ZiaMunir Ahmad Sheikh
Sep 15, 2014·Acta Biomaterialia·Helga BergmeisterHeinrich Schima
Nov 22, 2014·ACS Applied Materials & Interfaces·Sang-Ho YeWilliam R Wagner
Jun 18, 2015·Biofabrication·Tyler K MerceronAnthony Atala
Aug 28, 2015·ACS Applied Materials & Interfaces·Cancan XuYi Hong
Dec 10, 2016·ACS Applied Materials & Interfaces·Sang-Hyun PyoShaochen Chen
Mar 23, 2017·European Heart Journal·Thomas BartelSilvana Müller
Dec 9, 2017·International Journal of Pharmaceutics·G VerstraeteC Vervaet
Feb 27, 2018·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Bruna Nunes TeixeiraRossana Mara da Silva Moreira Thiré
Aug 21, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Shan-Hui HsuJui-Che Lin
Oct 10, 2016·ACS Biomaterials Science & Engineering·Liliang OuyangJason A Burdick
Mar 13, 2017·ACS Biomaterials Science & Engineering·Qing GaoYong He

❮ Previous
Next ❯

Citations

Feb 23, 2021·Frontiers in Bioengineering and Biotechnology·Na LiZhenyu Jason Zhang
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Samy A Madbouly
Apr 16, 2021·Chemical Reviews·Alina KirillovaMatthew L Becker

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.