A novel xenograft model of cutaneous T-cell lymphoma

Experimental Dermatology
Thorbjørn KrejsgaardAnders Woetmann

Abstract

Cutaneous T-cell lymphomas (CTCLs) are characterized by accumulation of malignant T cells in the skin. Early disease resembles benign skin disorders but during disease progression cutaneous tumors develop, and eventually the malignant T cells can spread to lymph nodes and internal organs. However, because of the lack of suitable animal models, little is known about the mechanisms driving CTCL development and progression in vivo. Here, we describe a novel xenograft model of tumor stage CTCL, where malignant T cells (MyLa2059) are transplanted to NOD/SCID-B2m(-/-) (NOD.Cg-Prkdc(scid) B2m(tm1Unc) /J) mice. Subcutaneous transplantation of the malignant T cells led to rapid tumor formation in 43 of 48 transplantations, whereas transplantation of non-malignant T cells isolated from the same donor did not result in tumor development. Importantly, the tumor growth was significantly suppressed in mice treated with vorinostat when compared to mice treated with vehicle. Furthermore, in most mice the tumors displayed subcutaneous and/or lymphatic dissemination. Histological, immunohistochemical and flow cytometric analyses confirmed that both tumors at the inoculation site, as well as distant subcutaneous and lymphatic tumors, originated f...Continue Reading

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Citations

Sep 6, 2012·Leukemia & Lymphoma·Ida Holst PedersenNiels Odum
Aug 16, 2012·Chronobiology International·Eiko Ishikawa-KobayashiAkio Fujimura
Mar 15, 2016·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Jan P NicolayCyrill Géraud
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Aug 26, 2011·Blood·Ulrik RalfkiaerNiels Odum
Jul 22, 2017·Blood Cancer Journal·B LauenborgA Woetmann
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Mar 8, 2017·Frontiers in Oncology·Rebecca KohnkenAnjali Mishra
Apr 24, 2018·The Journal of Investigative Dermatology·Xuesong Wu, Samuel T Hwang
Nov 13, 2017·The Journal of Investigative Dermatology·Melania H FanokSergei B Koralov

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