A novel zinc finger-containing RNA-binding protein conserved from fruitflies to humans

Genomics
F R JacksonE Rossi

Abstract

The Drosophila lark gene encodes an essential RNA-binding protein of the RNA recognition motif (RRM) class that is required during embryonic development. Genetic analysis demonstrates that it also functions as a molecular element of a circadian clock output pathway, mediating the temporal regulation of adult emergence in the fruitfly. We now report the molecular characterization of a human gene with significant similarity to lark. Based on fluorescence in situ hybridization and radiation hybrid mapping, the human gene has been localized to chromosome region 11q13; it is closely linked to several identified genes including the locus of Bardet-Biedl syndrome type 1. The lark-homologous human gene expresses a single 1.8-kb size class of mRNA in most or all tissues including brain. Additional database searches have identified a mouse counterpart that is virtually identical to the human protein. Similar to lark protein, both mammalian proteins contain two copies of the RRM-type consensus RNA-binding motif. Unlike most RRM family members, however, the Drosophila and mammalian proteins also contain a retroviral-type (RT) zinc finger that is situated 43 residues C-terminal to the second RRM element. Within a 184-residue segment spannin...Continue Reading

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Citations

Aug 16, 2006·DNA and Cell Biology·M Andrea Markus, Brian J Morris
May 18, 2007·Acta Pharmacologica Sinica·Wei JinZhi-Min Shao
Feb 1, 2007·Proceedings of the National Academy of Sciences of the United States of America·Shihoko KojimaHajime Tei
Oct 30, 2004·Journal of Cellular Biochemistry·Leslie C SutherlandCory D Morin
Aug 19, 2008·Neuroscience Letters·Thorsten PfuhlFriedrich A Grässer
Nov 6, 2007·Biochimica Et Biophysica Acta·Avril A MorrisonMichael R Ladomery
Feb 9, 2007·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Sachio Iwai, Makio Takeda
Jun 22, 2016·Scientific Reports·Hongmei YongBaorui Liu
Feb 13, 2001·European Journal of Biochemistry·H OttoF Hucho
May 26, 2004·The Journal of Biological Chemistry·Sven DiederichsCarsten Müller-Tidow
Jun 2, 2012·Journal of Biological Rhythms·Vasudha SundramF Rob Jackson
Oct 7, 2020·Proceedings of the National Academy of Sciences of the United States of America·Amir K ForoushaniStefan A Muljo
Oct 11, 2005·Journal of Proteome Research·Ramars AmanchyAkhilesh Pandey

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