A nuclear MAL-function links Rho to SRF

Molecular Cell
Jeffrey Settleman

Abstract

The activation of SRF-mediated transcription in response to Rho GTPase-induced actin assembly involves the ability of SRF to sense changes in the cellular level of actin monomers. An article in the May 2 issue of Cell identifies the transcription factor MAL as an actin binding protein that functions as an SRF coactivator and whose translocation from cytoplasm to nucleus depends on its dissociation from actin monomers (Miralles et al., 2003).

References

May 9, 2001·The Journal of Biological Chemistry·D Gineitis, R Treisman
May 30, 2002·The Journal of Cell Biology·Olivier GenesteRichard Treisman
Feb 26, 2003·American Journal of Respiratory Cell and Molecular Biology·Hong Wei LiuJulian Solway
May 7, 2003·Cell·Francesc MirallesRichard Treisman

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Citations

Jan 4, 2013·The Journal of Biological Chemistry·Ken'ichiro Hayashi, Tsuyoshi Morita
Jul 8, 2008·Biochemical Pharmacology·Gaelle KustermansSylvie Legrand-Poels
May 30, 2015·Scientific Reports·Ken'ichiro HayashiTsuyoshi Morita
Mar 4, 2005·The International Journal of Biochemistry & Cell Biology·Gertraud Orend
Apr 25, 2006·Cancer Letters·Gertraud Orend, Ruth Chiquet-Ehrismann
Sep 5, 2018·Development·Stéphanie BackerEvelyne Bloch-Gallego
Jun 8, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jianyuan ChaiAndrzej S Tarnawski
Jan 12, 2007·American Journal of Physiology. Cell Physiology·Susanne MuehlichMargarete Goppelt-Struebe
Jun 4, 2021·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Mugdha SawantRonen Schuster

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