A nuclear targeted dual-photosensitizer for drug-resistant cancer therapy with NIR activated multiple ROS

Chemical Science
Zhengze YuBo Tang

Abstract

Photodynamic therapy against cancer, especially multidrug resistant cancer, is limited seriously due to the efflux of photosensitizer molecules by P-glycoprotein, which leads to insufficient production of reactive oxygen species (ROS). For the purpose of abundant ROS generation and effective therapeutic response, herein, we firstly design and fabricate a nuclear targeted dual-photosensitizer for photodynamic therapy against multidrug resistant cancer. Molecule-photosensitizer Ce6 was selected and modified on the surface of core/shell structure nano-photosensitizer upconversion@TiO2 and then nuclear targeted peptides TAT were anchored for nuclear targeting. Through selective doping of rare earth elements Er and Tm, multiple ROS (˙OH, O2˙-, and 1O2) can be generated for the dual-photosensitizer and realize their functions synergistically using a single 980 nm NIR excitation. The nano-sized photosensitizer accompanied with nuclear targeting can effectively generate multiple ROS in the nucleus regardless of P-glycoprotein and directly break DNA double strands, which is considered as the most direct and serious lesion type for cytotoxic effects. Therefore, enhanced photodynamic therapy can be achieved against multidrug resistant can...Continue Reading

References

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Citations

Apr 11, 2019·Chemical Communications : Chem Comm·Wei PanBo Tang
May 11, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Gonzalo Ramírez-GarcíaPedro Salas
Aug 2, 2019·Chemical Communications : Chem Comm·Elyse M DigbyAndrew A Beharry
Aug 16, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Vladimíra PavlíčkováTomáš Ruml
Apr 16, 2020·Chemistry : a European Journal·Andres MachucaJose Luis Luque Garcia
Feb 23, 2020·Beilstein Journal of Nanotechnology·Maxime DemazeauBarbara Lonetti
May 10, 2017·Chemical Communications : Chem Comm·Ting-Ting ZhangHong-Yuan Chen
May 30, 2017·Chemical Science·Na LiBo Tang
Oct 11, 2016·Chemical Society Reviews·Zijian ZhouXiaoyuan Chen
May 16, 2018·Proceedings of the National Academy of Sciences of the United States of America·Zhixuan ZhouPeter J Stang
Aug 1, 2018·Chemical Society Reviews·Limin PanJianlin Shi
Sep 28, 2018·Advanced Materials·Wei-Hai ChenXian-Zheng Zhang
Jul 31, 2019·Chemical Science·Peng GaoBo Tang
Sep 16, 2020·Chemical Communications : Chem Comm·Yuanyuan ChenBo Tang
Aug 23, 2019·Chemical Communications : Chem Comm·Jun LuBo Tang
Jan 7, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Kai HanHeyou Han
Apr 20, 2017·Chemical Communications : Chem Comm·Na LiBo Tang
Mar 25, 2018·Advanced Materials·Hyek Jin KwonTaeghwan Hyeon
Nov 1, 2017·Nanoscale Horizons : the Home for Rapid Reports of Exceptional Significance in Nanoscience and Nanotechnolgy·Jin-Xuan FanXian-Zheng Zhang
Nov 4, 2020·Cancer Medicine·Lan MingDaozhen Chen
Nov 25, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Peipei JiaPiaoping Yang
Feb 7, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Zideng DaiZhenquan Tan
Nov 30, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Muhammad Muzamil KhanVladimir P Torchilin
Apr 17, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Ya-Xuan ZhuFu-Gen Wu

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Methods Mentioned

BETA
fluorescence
transmission electron microscopy
FRET
flow cytometry
xenograft

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