A nucleolar protein ApLLP induces ApC/EBP expression required for long-term synaptic facilitation in aplysia neurons

Neuron
Hyoung KimBong-Kiun Kaang

Abstract

In Aplysia, long-term synaptic plasticity is induced by serotonin (5-HT) or neural activity and requires gene expression. Here, we demonstrate that ApLLP, a novel nucleolus protein, is critically involved in both long-term facilitation (LTF) and behavioral sensitization. Membrane depolarization induced ApLLP expression, which activated ApC/EBP expression through a direct binding to CRE. LTF was produced by a single pulse of 5-HT 30 min after the membrane depolarization. This LTF was blocked when either ApLLP or ApC/EBP were blocked by specific antibodies. In contrast, ApLLP overexpression induced LTF in response to a single 5-HT treatment. Simultaneously, a siphon noxious stimulus (SNS) to intact Aplysia induced ApLLP and ApC/EBP expression, and single tail shock 30 min after SNS transformed short-term sensitization to long-term sensitization of siphon withdrawal reflex. These results suggest that ApLLP is an activity-dependent transcriptional activator that switches short-term facilitation to long-term facilitation.

References

Feb 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·B K KaangY Furukawa
Jul 24, 1992·Science·T J ShorsR F Thompson
Dec 27, 1996·Neuroscience Letters·B K Kaang
Oct 20, 1998·Journal of Neurobiology·S Finkbeiner, M E Greenberg
Feb 8, 2000·The Journal of Biological Chemistry·G G YingJ Golay
Feb 13, 2001·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·T NakayaY Kirino
Oct 9, 2003·The Biochemical Journal·Anthony K L LeungAngus I Lamond
Oct 28, 2003·Proceedings of the National Academy of Sciences of the United States of America·Maurizio GiustettoJames H Schwartz
May 14, 2004·Journal of Neurophysiology·Stéphane MarinescoThomas J Carew
Jul 9, 2004·Cellular Signalling·Amazia ZimberChristian Gespach
Oct 7, 2004·Neurobiology of Learning and Memory·Paul J Colombo
Nov 3, 2004·Brain Research. Molecular Brain Research·Peter GassRolf Sprengel
Nov 19, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ramal M S WeragodaEdgar T Walters
Mar 3, 2005·Histochemistry and Cell Biology·M O J Olson, Miroslav Dundr

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Citations

Nov 12, 2010·Amino Acids·Yanwei SunGert Lubec
Aug 27, 2009·Proceedings of the National Academy of Sciences of the United States of America·Yong-Seok LeeBong-Kiun Kaang
Sep 6, 2012·Proceedings of the National Academy of Sciences of the United States of America·Yong-Seok LeeBong-Kiun Kaang
Dec 31, 2009·The Journal of Biological Chemistry·Jason C PaikWeei-Chin Lin
Sep 23, 2008·Molecular Brain·Yong-Seok LeeBong-Kiun Kaang
Dec 15, 2007·Biochemical and Biophysical Research Communications·Jingxian Liu, Jianxing Song
Apr 10, 2013·Neurobiology of Learning and Memory·Ashly CyriacIrina E Calin-Jageman
Sep 6, 2008·Learning & Memory·Satoshi WatanabeAlan Gelperin

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