PMID: 8614622Apr 1, 1996Paper

A nucleolar RNA helicase recognized by autoimmune antibodies from a patient with watermelon stomach disease

Nucleic Acids Research
B C ValdezH Busch

Abstract

Watermelon stomach is characterized by prominent stripes of ectatic vascular tissue in the stomach similar to stripes on a watermelon; in patients with this disorder chronic gastrointestinal bleeding occurs and approximately half of these patients have associated autoimmune disorders. In the serum of one patient, an antinucleolar antibody titer of 1:25 600 was found; the antibodies specifically recognized an approximately 100 kDa nucleolar protein, which we referred to as the 'Gu' protein. Its cDNA was cloned and sequenced. The Gu protein is a member of a new subgroup of RNA helicases, the DEXD box family. Gu protein fused with glutathione S-transferase contains ATP-dependent RNA helicase activity which preferably translocates in the 5'-->3' direction. Its RNA folding activity, RNA-dependent ATPase and dATPase activities, and its translocation direction are similar to those of RNA helicase II [Flores-Rozas, H. and Hurwitz, J. (1993) J. Biol. Chem. 268, 21372-21383]. Sequencing of 209 amino acids of RNA helicase II peptides showed 96.7% identity with the cDNA-derived amino acid sequence of the Gu protein. The precise biological roles of this RNA helicase in the biogenesis of ribosomal RNA and the pathogenesis of watermelon disea...Continue Reading

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Citations

Dec 22, 1999·Biochemical and Biophysical Research Communications·K ZhuH Busch
Jun 29, 2007·Digestive Diseases and Sciences·Theresa A HerringJanos Zempleni
Feb 14, 2004·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Laura M StintonMarvin J Fritzler
Oct 13, 2000·European Journal of Biochemistry·B C Valdez
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Feb 2, 2002·The EMBO Journal·Jukka WestermarckDirk Bohmann
Oct 24, 2009·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Janeil M BelleTheodore N Pappas
May 1, 2012·Fibrogenesis & Tissue Repair·Oskar HallgrenGunilla Westergren-Thorsson
Apr 14, 2010·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·James M JamisonJack L Summers
Jan 19, 2013·World Journal of Gastrointestinal Endoscopy·Lorenzo FuccioFranco Bazzoli
May 1, 2001·Biochemical and Biophysical Research Communications·D Henning, B C Valdez
Mar 10, 2001·Biochemical and Biophysical Research Communications·K ZhuH Busch
Jul 14, 2004·Proceedings of the National Academy of Sciences of the United States of America·Benigno C ValdezMichael J Dixon
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Aug 16, 2008·FEBS Letters·Antoine MialonTim H Holmström
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Apr 2, 2016·Biochemical and Biophysical Research Communications·Yangchao DongYingfeng Lei
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Jun 16, 2012·RNA Biology·Lenz Steimer, Dagmar Klostermeier
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Jul 10, 2003·The Journal of Biological Chemistry·Hushan YangBenigno C Valdez
Jan 9, 2008·The Journal of Biological Chemistry·Tim H HolmströmJukka Westermarck
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Feb 3, 2005·Molecular and Cellular Biology·Chandrashekhar KorgaonkarDawn E Quelle
Feb 20, 2021·Bioscience, Biotechnology, and Biochemistry·Mengting GongShuanglin Xiang

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