A NWB-based dataset and processing pipeline of human single-neuron activity during a declarative memory task.

Scientific Data
Nand ChandravadiaUeli Rutishauser

Abstract

A challenge for data sharing in systems neuroscience is the multitude of different data formats used. Neurodata Without Borders: Neurophysiology 2.0 (NWB:N) has emerged as a standardized data format for the storage of cellular-level data together with meta-data, stimulus information, and behavior. A key next step to facilitate NWB:N adoption is to provide easy to use processing pipelines to import/export data from/to NWB:N. Here, we present a NWB-formatted dataset of 1863 single neurons recorded from the medial temporal lobes of 59 human subjects undergoing intracranial monitoring while they performed a recognition memory task. We provide code to analyze and export/import stimuli, behavior, and electrophysiological recordings to/from NWB in both MATLAB and Python. The data files are NWB:N compliant, which affords interoperability between programming languages and operating systems. This combined data and code release is a case study for how to utilize NWB:N for human single-neuron recordings and enables easy re-use of this hard-to-obtain data for both teaching and research on the mechanisms of human memory.

References

Jan 16, 2003·Neuron·Joseph R MannsLarry R Squire
Sep 2, 2003·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Bob Kemp, Jesus Olivan
May 12, 2009·Journal of Neuroscience Methods·Benjamin H BrinkmannMatt Stead
Jun 9, 2015·Nature Neuroscience·Ueli RutishauserAdam N Mamelak
Nov 22, 2015·Neuron·Jeffery L TeetersFriedrich T Sommer
Mar 15, 2016·Nature Neuroscience·Cyrille RossantKenneth D Harris
Jun 30, 2016·Human Brain Mapping·J Michael Tyszka, Wolfgang M Pauli
Apr 30, 2019·Trends in Cognitive Sciences·Ueli Rutishauser
Jun 27, 2019·Scientific Data·Cyril R PernetRobert Oostenveld

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Citations

Jul 17, 2021·Scientific Data·Csaba HorváthRichárd Fiáth

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Software Mentioned

PyNWB
OSort
NWB
NWBHDF5IO
nwbfile
N Python (
single
Export
all
NWBrunForAllCellsInSession

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