A One Step Procedure toward Conductive Suspensions of Liposome-Polyaniline Complexes.

Macromolecular Bioscience
Minoo EslamiDamia Mawad

Abstract

Interaction of conjugated polymers with liposomes is an attractive approach that benefits from both systems' characteristics such as electroactivity and enhanced interaction with cells. Conjugated polymer-liposome complexes have been investigated for bioimaging, drug delivery, and photothermal therapy. Their fabrication has largely been achieved by multistep procedures that require first the synthesis and processing of the conjugated polymer. Here, a new one step fabrication approach is reported based on in situ polymerization of a conjugated monomer precursor around liposomes. Polyaniline (PANI) doped with phytic acid is synthesized via oxidative polymerization in the presence of 1,2-dioleoyl-sn-glycero-3-phosphatidylcholine (DOPC) vesicles to produce a conductive aqueous suspension of Liposome-PANI complexes. PANI interacts with liposomes without disrupting the bilayer as shown using differential scanning calorimetry and fluorescence quenching studies of the hydrophobic Nile red probe. The electronic conductivity of the Liposome-PANI complexes, which stems from the doped PANI accessible on the liposome surface, is confirmed using conductive atomic force microscopy and electrochemical impedance spectroscopy. Further, short-ter...Continue Reading

References

Apr 20, 1994·Biochimica Et Biophysica Acta·A S UlrichA Watts
Aug 29, 2006·Biochimica Et Biophysica Acta·Soumi MukherjeeAmitabha Chattopadhyay
Sep 18, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Alik S WidgeMaria Kurnikova
Dec 19, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·An Thien Ngo, Gonzalo Cosa
May 8, 2010·Chemical Society Reviews·Judith F Rubinson, Yohani P Kayinamura
Feb 5, 2013·Expert Opinion on Drug Delivery·Francesco LaiChiara Sinico
Jun 11, 2015·Scientific Reports·Patrik K JohanssonOlle Inganäs
Jul 9, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jinping WangNan Li
Jul 20, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Judith E HoustonRachel C Evans
Oct 19, 2016·Journal of Agricultural and Food Chemistry·Jessica BollynErik Smolders
Feb 1, 2017·Science Advances·Damia MawadMolly M Stevens
Mar 28, 2017·Pharmaceutics·Upendra BulbakeWahid Khan
Jan 25, 2018·Biomaterials Science·Chen CuiDamia Mawad
Jan 27, 2018·Scientific Reports·Qinqin FeiYun Luo
Jun 8, 2018·Advanced Functional Materials·Michaella KapnisiMolly M Stevens
Jul 20, 2018·Advanced Materials·Erica Zeglio, Olle Inganäs
Apr 4, 2019·Advanced Healthcare Materials·Kristina Fidanovski, Damia Mawad

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Citations

Nov 17, 2020·Macromolecular Bioscience·Anna Herland, Myung-Han Yoon

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