A pair-rule function of odd-skipped in germband stages of Tribolium development.

Developmental Biology
Haewon JeonChong Pyo Choe

Abstract

While pair-rule patterning has been observed in most insects examined, the orthologs of Drosophila pair-rule genes have shown divergent roles in insect segmentation. In the beetle Tribolium castaneum, while odd-skipped (Tc-odd) was expressed as a series of pair-rule stripes, RNAi-mediated knockdown of Tc-odd (Tc-oddRNAi) resulted in severely truncated, almost asegmental phenotypes rather than the classical pair-rule phenotypes observed in germbands and larval cuticles. However, considering that most segments arise later in germband stages of Tribolium development, the roles of Tc-odd in segmentation of growing germbands could not be analyzed properly in the truncated Tc-oddRNAi germbands. Here, we investigated the segmentation function of Tc-odd in germband stages of Tribolium development by analyzing Tc-oddRNAi embryos that resumed germband extension. In the larval cuticles of Tc-oddRNAi embryos, normal mandibular and maxillary and loss of the labial segments were consistent in the head, whereas a broad range of segmentation defects including loss or fusion of thoracic and/or abdominal segments was observed in the trunk. Interestingly, a group of Tc-oddRNAi germbands showed pair-rule-like defects in the segmental stripes of th...Continue Reading

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Citations

Apr 20, 2021·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Susanne Thümecke, Reinhard Schröder

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