Apr 11, 2020

Exploring the genomic and proteomic variations of SARS-CoV-2 spike glycoprotein: a computational biology approach

BioRxiv : the Preprint Server for Biology
S. M. LokmanM. M. Hasan

Abstract

The newly identified SARS-CoV-2 has now been reported from around 183 countries with more than a million confirmed human cases including more than 68000 deaths. The genomes of SARS-COV-2 strains isolated from different parts of the world are now available and the unique features of constituent genes and proteins have gotten substantial attention recently. Spike glycoprotein is widely considered as a possible target to be explored because of its role during the entry of coronaviruses into host cells. We analyzed 320 whole-genome sequences and 320 spike protein sequences of SARS-CoV-2 using multiple sequence alignment tools. In this study, 483 unique variations have been identified among the genomes including 25 non-synonymous mutations and one deletion in the spike protein of SARS-CoV-2. Among the 26 variations detected, 12 variations were located at the N-terminal domain and 6 variations at the receptor-binding domain (RBD) which might alter the interaction with receptor molecules. In addition, 22 amino acid insertions were identified in the spike protein of SARS-CoV-2 in comparison with that of SARS-CoV. Phylogenetic analyses of spike protein revealed that Bat coronavirus have a close evolutionary relationship with circulating...Continue Reading

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Mentioned in this Paper

Study
Pathogenic Aspects
Pathogenesis
Genome
Genes
Gene Expression
Fejervarya orissaensis
Analysis
Malignant Neoplasms
Pan-neural Process

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