A Panel of Cancer Testis Antigens and Clinical Risk Factors to Predict Metastasis in Colorectal Cancer

Journal of Biomarkers
Ramyar MolaniaBahar Mahjoubi

Abstract

Colorectal cancer (CRC) is the third common carcinoma with a high rate of mortality worldwide and several studies have investigated some molecular and clinicopathological markers for diagnosis and prognosis of its malignant phenotypes. The aim of this study is to evaluate expression frequency of PAGE4, SCP-1, and SPANXA/D cancer testis antigen (CTA) genes as well as some clinical risk markers to predict liver metastasis of colorectal cancer patients. The expression frequency of PAGE4, SCP-1, and SPANXA/D cancer/testis antigen (CTA) genes was obtained using reverse transcription polymerase chain reaction (RT-PCR) assay in 90 colorectal tumor samples including both negative and positive liver metastasis tumors. Statistical analysis was performed to assess the association of three studied genes and clinical risk factors with CRC liver metastasis. The frequency of PAGE4 and SCP-1 genes expression was significantly higher in the primary tumours with liver metastasis when statistically compared with primary tumors with no liver metastasis (P < 0.05). Among all clinical risk factors studied, the lymph node metastasis and the depth of invasion were statistically correlated with liver metastasis of CRC patients. In addition, using multi...Continue Reading

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Jan 20, 2019·Journal of Experimental & Clinical Cancer Research : CR·Chengcheng LvYu Zeng
Feb 12, 2020·Clinical Sarcoma Research·Anna DanilovaIrina Baldueva
Jun 21, 2017·Terapevticheskiĭ arkhiv·N R HilalA V Karaulov

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Methods Mentioned

BETA
PCR
electrophoresis
xenografts

Software Mentioned

SPSS

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