A Panel of MicroRNA Signature as a Tool for Predicting Survival of Patients with Urothelial Carcinoma of the Bladder

Disease Markers
Teruo InamotoHaruhito Azuma

Abstract

MicroRNA (miRNA) expression is altered in urologic malignancies, including urothelial carcinoma of the bladder (UCB). Individual miRNAs have been shown to modulate multiple signaling pathways that contribute to BC. To identify a panel of miRNA signature that can predict aggressive phenotype from normal nonaggressive counterpart using miRNA expression levels and to assess the prognostic value of this specific miRNA markers in patients with UCB. To determine candidate miRNAs as prognostic biomarkers for dividing aggressive type of UCB, miRNA expression was profiled in patients' samples with an aggressive phenotype or nonaggressive phenotype using 3D-Gene miRNA labeling kit (Toray, Japan). To create a prognostic index model, we used the panel of 9-miRNA signature based on Cancer Genome Atlas (TCGA) data portal (TCGA Data Portal (https://tcgadata.nci.nih.gov/tcga/tcgaHome2.jsp)). miRNA expression data and corresponding clinical data, including outcome and staging information of 84 UCB patients, were obtained. The Kaplan-Meier and log-rank test were performed to quantify the survival functions in two groups. Deregulation of nine miRNAs (hsa-miR-99a-5p, hsa-miR-100-5p, hsa-miR-125b-5p, hsa-miR-145-5p, hsa-miR-4324, hsa-miR-34b-5p, hs...Continue Reading

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Citations

Dec 20, 2019·The Journal of International Medical Research·Hailin LiDaxun Piao
Oct 17, 2019·Cancers·Edyta Marta BorkowskaZbigniew Jabłonowski
Feb 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tomhiro MastuoHideki Sakai
Sep 29, 2020·Frontiers in Cell and Developmental Biology·Xueliang WuTian Li
Jan 6, 2021·Journal of Oral Biology and Craniofacial Research·Alieh FarshbafSeyed Abdolrahim Rezaee
Aug 17, 2021·Journal of Immunology Research·Hai-Peng WeiLingzhang Meng
Nov 23, 2021·Frontiers in Oncology·Yu MeiHuanjie Yang

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Methods Mentioned

BETA
chip
RNAseq

Software Mentioned

RNAseq

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