A paper-based SERS test strip for quantitative detection of Mucin-1 in whole blood

Talanta
Shan-Wen HuHong-Yuan Chen

Abstract

A paper-based SERS test strip combining strengths of paper chip and Raman active substrate was demonstrated to overcome challenges in spectroscopic sensing of complicated samples and realize quantitative detection of disease markers in whole blood. The precisely controlled Au NPs were not only capable of generating condensed hot spots on the fibers, but also enhanced the size exclusion effect of paper, resulting in the novel performance on both SERS detection and sample pretreatment. A biosensor for Mucin-1 is developed by equipping the Au NPs with aptamer. Combining all these merits, this small, cheap and portable test strip might find wide application in clinical diagnosis and health evaluation.

Citations

Dec 14, 2019·The Analyst·Juanjuan LiuSebastian Wachsmann-Hogiu
Dec 4, 2019·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Xuanyu ShaWu-Li-Ji Hasi
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Nov 30, 2018·The Analyst·Fanyu ZengJinhong Guo
Nov 4, 2020·Nanomedicine·Ting LinTing-Ting Zeng
Oct 7, 2020·Biosensors & Bioelectronics·Tao MingXinxia Cai
Mar 25, 2019·Analytica Chimica Acta·Stephen M Restaino, Ian M White
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May 28, 2021·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Abishek HariharanPrathyusha Vadlamudi
Jul 31, 2021·Biomicrofluidics·Hao YuanChien-Fu Chen
Sep 28, 2018·Analytical Chemistry·Hua Li, Andrew J Steckl

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