A paradigm shift in enteric coating: achieving rapid release in the proximal small intestine of man

Journal of Controlled Release : Official Journal of the Controlled Release Society
Fang Liu, A W Basit

Abstract

The in vivo performance of a novel enteric double-coating technology designed to accelerate release in the proximal small intestine of humans was investigated. Tablet cores were coated with a double layer formulation consisting of an inner layer of EUDRAGIT L 30 D-55 neutralised to pH 6.0 in the presence of 10% citric acid, and an outer layer of standard EUDRAGIT L 30 D-55. A conventional single coating of EUDRAGIT L 30 D-55 was also applied to tablets for comparison purposes, with the identical coating formulation and thickness (5mg/cm(2)) as the outer layer of the double coating. Eight fasted volunteers received the double-coated and single-coated tablets in a two-way crossover study. The formulations were radiolabelled and followed by gamma scintigraphy; the disintegration times and positions were recorded. After leaving the stomach, tablets coated with the single-coating formulation showed a significant time delay before disintegration occurred in the mid to distal small intestine, with a mean disintegration time of 66 ± 22 min post gastric emptying. The double-coated tablets disintegrated earlier at 28 ± 6min post gastric emptying with consistent disintegration in the proximal small intestine. The accelerated in vivo disin...Continue Reading

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Dec 9, 2008·International Journal of Pharmaceutics·Fang LiuAbdul W Basit
Nov 26, 2009·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Fang LiuAbdul W Basit

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Citations

Oct 16, 2013·International Journal of Pharmaceutics·Kathrin Nollenberger, Jessica Albers
Oct 30, 2012·Expert Opinion on Drug Delivery·Seema ThakralDipak K Majumdar
Jan 21, 2015·Critical Reviews in Biotechnology·Russell G A Jones, Angela Martino
Jan 26, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·F J O VarumA W Basit
Jun 12, 2012·International Journal of Pharmaceutics·Lucia ZemaAndrea Gazzaniga
Aug 23, 2011·International Journal of Pharmaceutics·Felipe J O VarumAbdul W Basit
Jan 25, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Fang LiuAbdul W Basit
Mar 29, 2016·The Journal of Pharmacy and Pharmacology·Hiroko ShibataYukihiro Goda

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