A paradigm to investigate the regulation of cocaine self-administration in human cocaine users: a randomized trial

Psychopharmacology
W J LynchRobert T Malison

Abstract

We recently conducted a pilot study supporting the feasibility, safety, and validity of a human laboratory model of ad libitum cocaine administration in which subjects self-selected the timing of infusions. The current study extends this work to include a randomized design with a test-retest component in a larger sample. To investigate the regulation of cocaine intake by humans and its effects on subjective and cardiovascular responses. Subjects were 14 non-treatment seeking volunteers (10 M, 4 F) with cocaine abuse/dependence. Subjects self-administered cocaine infusions (0, 8, 16, and 32 mg/70 kg) over a 2-h period under a fixed ratio 1, 5-min time-out schedule on 4 consecutive days. A fifth session was conducted at 16-mg dose to assess the paradigm's test-retest reliability. Subjects regulated their cocaine intake in a dose-dependent fashion. Self-reports of cocaine-related subjective effects (e.g., "high" and "stimulated") also varied in a dose-dependent way. Test-retest data and the randomized design support the conclusion that such effects are not due to tolerance or other experimental artifacts. The current study replicates prior work demonstrating the feasibility, safety, and validity of our human laboratory paradigm of...Continue Reading

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Citations

Feb 24, 2007·Psychopharmacology·Amandine Zittel-LazariniSerge H Ahmed
Apr 8, 2014·Nature Neuroscience·Ingo WilluhnPaul E M Phillips
Aug 28, 2012·Pharmacology, Biochemistry, and Behavior·D MatuskeyR T Malison
Dec 17, 2009·Pharmacology, Biochemistry, and Behavior·Gustavo A AngaritaRobert T Malison
Oct 16, 2008·Addiction·Peter T MorganRobert T Malison
Jan 21, 2012·Drug and Alcohol Review·Sara SantosUNKNOWN ITINERE Project Group
Mar 22, 2006·Pharmacology, Biochemistry, and Behavior·Rasmon KalayasiriRobert T Malison
Jan 21, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·Richard De La GarzaKathryn A Cunningham
Nov 14, 2014·Journal of Dual Diagnosis·Yilang TangRobert O Cotes
Sep 28, 2005·Journal of Psychosomatic Research·Giorgio GrossiKarin Holm
Nov 27, 2010·Pharmacology, Biochemistry, and Behavior·Aaron EttenbergOsnat Ben-Shahar
Sep 19, 2014·The International Journal of Behavioral Nutrition and Physical Activity·Emely De VetTania Gaspar
Dec 1, 2006·Journal of Ethnicity in Substance Abuse·Victor B Stolberg

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