A parenteral nutrition regimen with ornithine substituted for arginine alters the amino acid, but not polyamine, content of the ward colon tumor

Nutrition and Cancer
V B Grossie, K Nishioka

Abstract

Substituting ornithine for arginine in total parenteral nutrition (TPN) regimens eliminates the TPN-enhanced growth of the Ward colon tumor. Plasma arginine was increased when tumor growth was increased, suggesting a role for this amino acid. The erythrocyte polyamine content, however, was elevated in rats receiving both TPN regimens, indicating an increased synthesis and availability for tumors receiving arginine- and ornithine-containing regimens. The objective of this study, therefore, was to evaluate the effect of substituting ornithine for arginine in a TPN regimen on the amino acid and polyamine content of the Ward colon tumor compared with that of rats fed chow ad libitum. Male Fischer 344 rats with a transplantable Ward colon tumor implanted subcutaneously were randomized to three groups and fed for four days. One group received a TPN regimen with arginine (1,300 mg/100 ml, ENA), whereas a second group received a regimen with an isonitrogenous substitution of ornithine (ENO). A control group received chow ad libitum. Serum and tumors were evaluated for arginine, ornithine, lysine, and polyamine content. The arginine concentration in the serum and tumor increased when rats received ENA. In contrast, the serum and tumor a...Continue Reading

References

Mar 1, 1978·The Journal of Nutrition·J A Milner, W J Visek
Apr 1, 1992·Clinical Science·K G ParkP J Garlick
Dec 1, 1988·The Journal of Surgical Research·J V ReynoldsJ M Daly
Nov 15, 1988·International Journal of Cancer. Journal International Du Cancer·K NishiokaD M Ota
Apr 1, 1996·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·G CasoP J Garlick

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Citations

Jul 26, 2000·Medicine and Science in Sports and Exercise·C J FieldV C Pratt

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