A patent review of myeloperoxidase inhibitors for treating chronic inflammatory syndromes (focus on cardiovascular diseases, 2013-2019).

Expert Opinion on Therapeutic Patents
Jalal SoubhyeFrançois Dufrasne

Abstract

Myeloperoxidase (MPO) is an immune enzyme found in neutrophils and macrophages. It produces the highly oxidative compound HOCl from H2O2 and Cl- ions inside the phagosome of the neutrophil. Leakage of the enzyme outside the cell causes oxidative damages for the biomolecules promoting many inflammatory diseases such as atherosclerosis. Thus, there is a real interest to develop potent inhibitors of MPO as non-steroidal anti-inflammatory agents. This review highlights the several published MPO inhibitors, their activity, and the challenges met during the development of these compounds. This article covers the patent literature published on MPO inhibitors from 2013 to 2019, as well as the potential use of these compounds as therapeutics for inflammatory syndromes, especially that plays an important role in the initiation and progression of atherosclerosis. To date, many MPO inhibitors with different structures have been studied, many of which have prominent inhibitory activities. Furthermore, the specificity of these drugs offers hope for the targeted therapy of inflammatory syndromes. Although many data have proved that MPO can contribute to several chronic inflammatory syndromes, the usefulness of MPO inhibitors in preventing and...Continue Reading

References

Nov 5, 1987·Biochimica Et Biophysica Acta·H HooglandR Wever
Nov 23, 1988·Biochimica Et Biophysica Acta·A J Kettle, C C Winterbourn
Dec 1, 1968·American Journal of Public Health and the Nation's Health·B B Breese
May 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·K J Williams, I Tabas
Aug 1, 1996·Archives of Biochemistry and Biophysics·W A Prütz
Oct 23, 1997·Journal of Neuroimmunology·R M NagraW F Reynolds
Dec 31, 1997·The Journal of Clinical Investigation·D G Harrison
Feb 22, 2000·The Journal of Biological Chemistry·H M Abu-Soud, S L Hazen
Sep 23, 2000·Nature·A J Lusis
Jun 12, 2003·International Journal of Cancer. Journal International Du Cancer·Samart PakakasamaGail E Tomlinson
Nov 6, 2003·Redox Report : Communications in Free Radical Research·Jürgen ArnholdChristian Obinger
Dec 6, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Eugenia PoliakovStanley L Hazen
Jul 17, 2004·Journal of Neurochemistry·Pattie S GreenJay W Heinecke
Feb 4, 2005·Journal of Leukocyte Biology·Seymour J Klebanoff
Mar 26, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Stephen J Nicholls, Stanley L Hazen
Mar 30, 2005·Biochemical Pharmacology·Walter JantschkoChristian Obinger
Jul 15, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Dong-Kug ChoiSerge Przedborski
Nov 1, 2005·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·V F XimenesI L Brunetti
May 16, 2006·Biochimica Et Biophysica Acta·Ernst MalleMichael J Davies
Jun 27, 2007·British Journal of Pharmacology·E MalleC Obinger
Dec 8, 2009·Gynecologic Oncology·Ghassan M SaedAdnan R Munkarah
Oct 27, 2010·Environmental Health : a Global Access Science Source·Lotte JacobsLuc Int Panis
Feb 19, 2011·Rheumatology International·Raissa Maria Sampaio Neves FernandesEmília Inoue Sato
Aug 30, 2011·BMB Reports·Jong-Gil Park, Goo Taeg Oh
Sep 2, 2011·The Journal of Biological Chemistry·Anna-Karin TidénAnthony J Kettle
Nov 1, 2009·Expert Review of Clinical Pharmacology·Thomas Senderovitz
Apr 24, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anne M van der DoesPeter H Nibbering
Aug 15, 2012·Neurological Research·Fernando Sánchez-LópezIsaac Túnez
Oct 16, 2012·Journal of Leukocyte Biology·Seymour J KlebanoffWilliam M Nauseef
May 8, 2013·Journal of Leukocyte Biology·David ErmertConstantin F Urban
Jul 19, 2013·PloS One·Benjamin PulliJohn W Chen
Jul 26, 2013·Journal of Lipid Research·Hao ZhangKirkwood A Pritchard
Sep 17, 2013·Archives of Biochemistry and Biophysics·Martina Paumann-PageAnthony J Kettle

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Related Papers

Bioorganic & Medicinal Chemistry Letters
Semira Galijasevic
Current Drug Metabolism
Tamara Lazarevic-PastiVesna Vasic
Future Cardiology
Baris Ikitimur, Bilgehan Karadag
© 2022 Meta ULC. All rights reserved