A path from melanocyte stem cells to cutaneous melanoma illuminated by UVB

Molecular & Cellular Oncology
Hyeongsun Moon, A C White

Abstract

The relationship between melanocyte stem cells (MCSCs) and melanoma has been unclear. We recently demonstrated that melanoma-prone MCSCs are able to initiate cutaneous melanoma following stem cell activation through ultraviolet-B (UVB) exposure or natural stem cell cycling. Conversely, MCSC quiescence is sufficient to suppress tumorigenesis. This provides new insight into the role of environmental factors in tumor initiation from adult stem cells.

References

Mar 14, 2009·Nature Genetics·David DankortMarcus Bosenberg
Apr 20, 2011·Proceedings of the National Academy of Sciences of the United States of America·Andrew C WhiteWilliam E Lowry
Dec 18, 2013·Nature Cell Biology·A C WhiteW E Lowry
Sep 23, 2014·Trends in Cell Biology·Andrew C White, William E Lowry
May 11, 2016·The Journal of Investigative Dermatology·William E LowryAndrew C White

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Citations

Nov 25, 2018·Experimental Dermatology·Hyeongsun MoonAndrew C White
Apr 3, 2020·Experimental & Molecular Medicine·Hyeongsun MoonAlexander D Borowsky

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