PMID: 7516403Jul 1, 1994Paper

A pathogenic autoimmune process targeted at a surrogate epitope

The Journal of Experimental Medicine
A T KozhichI Gery

Abstract

Immunization with the retinal interphotoreceptor retinoid-binding protein (IRBP) induces in a variety of animals an inflammatory eye disease, experimental autoimmune uveoretinitis (EAU). We have previously shown that sequence 1181-1191 of bovine IRBP (BOV 1181-1191) is immunodominant and highly uveitogenic and immunogenic in Lewis rats. Sequence 1181-1191 of the rat IRBP (RAT 1181-1191) differs from BOV 1181-1191 by two residues, at positions 1188 and 1190, that are pivotal for the immunological activity of the bovine epitope. Here we show that, unlike its bovine homologue, RAT 1181-1191 did not induce EAU or an immune response in Lewis rats. The immunological inactivity of RAT 1181-1191 in Lewis rats is due at least in part to its poor affinity toward the antigen-presenting cells of these rats, as shown by its failure to compete with binding of BOV 1181-1191 to Lewis adherent spleen cells. Moreover, unlike all other known autologous homologues of immunopathogenic epitopes, RAT 1181-1191 was not recognized by lymphocytes sensitized against BOV 1181-1191 and failed to stimulate proliferation, uveitogenic capacity or signal transduction in these cells. These findings thus suggest that RAT 1181-1191 is not a likely target for lymp...Continue Reading

References

Nov 1, 1977·The Journal of Experimental Medicine·R F KiblerD E McFarlin
Dec 14, 1991·Lancet·J V Forrester
Jan 1, 1986·Annual Review of Immunology·A WeissJ Stobo
Jan 1, 1993·Annual Review of Immunology·E E SercarzK Moudgil
Jul 1, 1993·Journal of Neuroimmunology·K E Gould, R H Swanborg

❮ Previous
Next ❯

Citations

Dec 1, 1994·Current Opinion in Immunology·I Gery, J W Streilein
Jul 16, 2005·Ocular Immunology and Inflammation·Charles E Thirkill
Nov 12, 2002·International Reviews of Immunology·Grazyna Adamus, Chi-Chao Chan
Mar 4, 2000·International Immunology·K M DrescherM Rodriguez
Oct 22, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hui ShaoDeming Sun
Mar 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·K D MoudgilE E Sercarz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.