PMID: 3212892Nov 1, 1988Paper

A pathologic and toxicologic evaluation of veal calves fed large amounts of zinc

Veterinary Pathology
T W GrahamM S Clegg

Abstract

Tissues were examined from 26 male Holstein veal calves given large amounts of dietary zinc. All calves had been fed 706 micrograms zinc/g of milk replacer for 28 days before the first death occurred. Calves died naturally (14, group A) or were euthanatized (12, group B) after 23 days of feeding a lower concentration of zinc (150 micrograms/g). Average amounts of zinc in liver (wet weight) were 345.72 micrograms/g (group A) and 344.84 micrograms/g (group B). Mean kidney zinc concentrations were 219.0 micrograms/g (group A) and 252.38 micrograms/g (group B). Tissue manganese, copper, and iron levels were normal. Changes at necropsy included pneumonia, fluid digesta, and petechiae and infarcts in liver, kidney, and heart (as a result of bacterial infections). Histological changes that were directly attributed to dietary zinc intake were: marked atrophy and necrosis of pancreatic acinar tissue (group A); multifocal fibrosis of pancreatic acini (group B); multifocal renal cortical fibrosis with necrosis in convoluted tubules and loops of Henle, and with intratubular mineralization (groups A and B). Hepatic midzonal mineralization and fibrosis of the adrenal zona glomerulosa were seen in group B calves.

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Citations

Jun 1, 1994·Environmental Health Perspectives·C T WalshP J Fraker
Nov 6, 2004·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Kathryn C GambleThomas P Alvarado
Nov 6, 2004·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Michael M GarnerRobert W Nordhausen
Apr 1, 1995·Annals of Emergency Medicine·P E McKinneyK Kulig
Aug 13, 2004·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Birgit PuschnerMark C Thurmond
Jan 1, 1994·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·T W GrahamC L Keen
Jul 1, 1991·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·R J AulerichT P Mullaney

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