PMID: 8608489Mar 1, 1996Paper

A pathologic study of Hodgkin's disease in Korea and its association with Epstein-Barr virus infection

Cancer
J HuhC Kim

Abstract

The incidence of Hodgkin's disease (HD) in Korea and other Asian countries is much lower than in western countries and its association with the Epstein-Barr virus has not been well characterized. We evaluated the clinical, morphologic, and immunohistochemical features of 87 patients with Hodgkin's disease and also analyzed patients for Epstein-Barr virus (EBV) using in situ hybridization for EBV DNA, RNA, and latent membrane protein (LMP1). There were 68 males and 19 females, with a mean age of 38 years. Mixed cellularity was the most prevalent subtype. Expression of EBV RNA (EBER:EBV-encoded RNA) was detected in 60 of 87 cases (69%): 1 of 1 (100%) with lymphocyte predominance, nodular; 4 of 7 (57%) with lymphocyte predominance, diffuse; 10 of 17 (59%) with nodular sclerosis; 38 of 51 (75%) with mixed cellularity; and 7 of 11 (64%) with lymphocyte depletion. Positivity was higher in advanced clinical stages; 4 of 7 patients (57%) with Stage I; 6 of 12 patients (50%) with Stage II: 7 of 9 patients (75%) with Stage III; and 5 of 5 patients (100%) with Stage IV HD EBV DNA was detected in 9 of 25 cases tested (36%). LMP1 was seen in 39 of 87 cases (45%). EBER and LMP1 positivity were higher in children and older adults than in adul...Continue Reading

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Citations

Jun 1, 2011·Journal of Hematopathology·Josée AudouinDennis D Weisenburger
Nov 5, 1997·Annals of the New York Academy of Sciences·H P Wagner, V Antic
Nov 26, 2005·Clinical and Laboratory Haematology·M-Y LeeA-C Feng
Mar 5, 2011·Hematological Oncology·Mário Henrique M BarrosGerald Niedobitek
Jul 12, 2012·The Korean Journal of Hematology·Jooryung Huh
Mar 29, 2002·Journal of Medical Virology·Insun KimYoung-Sik Kim

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