PMID: 7018427Jun 1, 1981Paper

A pathophysiologic study of the hypertension associated with burn injury in children

Annals of Surgery
M B PoppB G MacMillan

Abstract

Measurements of cardiac output, blood volume, plasma renin activity (PRA), serum aldosterone, plasma and urinary catecholamine levels, serum and urinary electrolyte levels, and of transfusion and fluid therapy have been made in eight hypertensive and seven normotensive burned children. Studies were conducted during the acute phase of burn injury when hypertension was first diagnosed and were repeated just before discharge from the hospital. Hypertensive patients perfused at an inappropriately high total peripheral resistance and hypervolemia was demonstrated in the hypertensive patients. No differences could be demonstrated between hypertensive or normotensive patients in PRA, aldosterone, catecholamine, or electrolyte levels. These data indicate that both the hypervolemia and the vasoconstrictor activity of PRA and/or catecholamines are present when hypertension develops in these patients. These data suggest that the renin-angiotension-aldosterone system is directly stimulated as part of the neuroendocrine response to trauma.

References

Sep 18, 1976·Lancet·R Davies, J D Slater
Oct 1, 1977·Surgery, Gynecology & Obstetrics·M B PoppB G MacMillan
Mar 1, 1978·The Journal of Trauma·B FalknerA Bendlin
Oct 1, 1977·Annals of Surgery·D W WilmoreB A Pruitt
Feb 1, 1973·Analytical Biochemistry·P G Passon, J D Peuler
Nov 1, 1972·The Australian and New Zealand Journal of Surgery·B S Douglas, M J Broadfoot
Jul 1, 1974·The Journal of Trauma·J W BaneM D Turner
Jan 1, 1972·The Journal of Clinical Endocrinology and Metabolism·T ItoR Horton
Apr 1, 1980·Annals of Surgery·M B PoppB G MacMillan
Apr 1, 1957·Annals of Surgery·M GOODALLB W HAYNES

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Citations

Mar 6, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Matthew M Grinsell, Victoria F Norwood
Dec 29, 2016·Burns : Journal of the International Society for Burn Injuries·Ian J StewartKevin K Chung
Jan 1, 2014·Expert Review of Endocrinology & Metabolism·Federica D'AstaMaria Luisa Brandi
Dec 12, 2013·Journal of Hypertension·Krishna ArunVeerappan Narayanan

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