A Patient-Level Model to Estimate Lifetime Health Outcomes of Patients With Type 1 Diabetes.

Diabetes Care
An Tran-DuyPhilip Clarke

Abstract

To develop a patient-level simulation model for predicting lifetime health outcomes of patients with type 1 diabetes and as a tool for economic evaluation of type 1 diabetes treatment based on data from a large, longitudinal cohort. Data for model development were obtained from the Swedish National Diabetes Register. We derived parametric proportional hazards models predicting the absolute risk of diabetes complications and death based on a wide range of clinical variables and history of complications. We used linear regression models to predict risk factor progression. Internal validation was performed, estimates of life expectancies for different age-sex strata were computed, and the impact of key risk factors on life expectancy was assessed. The study population consisted of 27,841 patients with type 1 diabetes with a mean duration of follow-up of 7 years. Internal validation showed good agreement between the predicted and observed cumulative incidence of death and 10 complications. Simulated life expectancy was ∼13 years lower than that of the sex- and age-matched general population, and patients with type 1 diabetes could expect to live with one or more complications for ∼40% of their remaining life. Sensitivity analysis s...Continue Reading

References

May 29, 1987·The American Journal of Cardiology·P W WilsonW B Kannel
Oct 8, 1999·The New England Journal of Medicine·E E CalleC W Heath
Nov 18, 2000·Diabetes Research and Clinical Practice·J B BrownA Russell
Nov 29, 2001·Clinical Science·R J StevensUNKNOWN United Kingdom Prospective Diabetes Study (UKPDS) Group
Mar 29, 2003·Diabetes Care·Soffia GudbjörnsdottirUNKNOWN Steering Committee of the Swedish National Diabetes Register
Aug 31, 2004·Diabetes Care·UNKNOWN American Diabetes Association Consensus Panel
Jul 29, 2006·Diabetes Care·Janice C ZgiborMark S Roberts
Sep 5, 2008·PharmacoEconomics·Karl Claxton
Dec 26, 2008·European Heart Journal·Jose LealPhilip M Clarke
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
Jun 9, 2009·European Journal of Epidemiology·Jonas F LudvigssonAnders Ekbom
Jun 11, 2011·BMC Public Health·Jonas F LudvigssonPetra Otterblad Olausson
Sep 20, 2012·Medical Decision Making : an International Journal of the Society for Medical Decision Making·David M EddyUNKNOWN ISPOR-SMDM Modeling Good Research Practices Task Force
Jun 26, 2013·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Andrew J PalmerWilliam Valentine
Dec 9, 2014·Diabetic Medicine : a Journal of the British Diabetic Association·S WolowaczA Briggs
Jan 1, 2015·Diabetes Research and Clinical Practice·Björn Eliasson, Soffia Gudbjörnsdottir
Mar 17, 2015·Journal of Diabetes and Its Complications·Vincenzo LaganiIoannis Tsamardinos
Sep 2, 2015·Journal of Biomedical Informatics·Simone MariniRiccardo Bellazzi
Jan 23, 2016·PharmacoEconomics·Martin HenrikssonMichael Willis
Apr 6, 2016·Diabetologia·Dennis PetriePhilip Clarke
Nov 20, 2016·Journal of Orthopaedic Surgery and Research·Robert G DekkerAnish R Kadakia
Apr 14, 2017·The New England Journal of Medicine·Aidin RawshaniSoffia Gudbjörnsdottir
Jul 18, 2017·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·William J ValentineKristina Boye
Oct 7, 2017·European Journal of Epidemiology·Hannah Louise BrookeRickard Ljung
Jun 7, 2018·Diabetes Technology & Therapeutics·Kathryn W Weaver, Irl B Hirsch
Jun 19, 2018·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Andrew J PalmerPhilip M Clarke
Jun 20, 2018·Journal of Diabetes Science and Technology·Gunnar Nordin
Jan 19, 2019·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Anirban BasuElbert Huang

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Citations

Jul 27, 2021·Diabetologia·An Tran-DuyAndrew J Palmer
Jan 27, 2022·The Journal of Clinical Endocrinology and Metabolism·Amelia S WallaceElizabeth Selvin

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Methods Mentioned

BETA
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Stata
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