A patient with 17 primary tumours and a germ line mutation in TP53: tumour induction by adjuvant therapy?

Clinical Oncology : a Journal of the Royal College of Radiologists
C NuttingR Eeles

Abstract

We report the case history of a woman with a germ line mutation in the TP53 gene who developed 17 separate primary tumours. The incidence of new tumours rose steeply after adjuvant tamoxifen treatment for breast cancer and adjuvant vaginal vault radiotherapy for endometrial cancer. This increase could be due to cumulative genetic damage from environmental agents and the fact that the patient lived to the relatively late age of 60 years, or to a high inherent deleterious somatic mutation rate, which could represent the inability of cells from patients with TP53 mutations to repair therapy-induced genetic damage.

Citations

Oct 17, 2008·Developmental Disabilities Research Reviews·Nicole J Ullrich
Mar 27, 2013·Nature Reviews. Clinical Oncology·Lois B TravisAndrea K Ng
Jan 1, 2014·Health Physics·Lois B TravisJohn D Boice
Sep 26, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Marie E WoodLois B Travis
Oct 14, 2008·Health Physics·James M Allan
Jul 14, 2020·Pediatric Blood & Cancer·Morgane PondromLaurence Brugières
May 28, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gaëlle BougeardThierry Frebourg

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