A patient with Bartter syndrome accompanying severe growth hormone deficiency and focal segmental glomerulosclerosis.

Clinical and Experimental Nephrology
Ipek AkilBetul Ersoy

Abstract

Bartter syndrome is a rare autosomal recessive, salt-losing disorder characterized by hypokalemic hypochloremic metabolic alkalosis. A 10-year-old boy had severe growth retardation (height standard deviation score -8.15). He had a thin, triangular face, prominent ears and forehead, and big eyes. Megacystis, bilateral hydroureteronephrosis, and residual urine were detected in ultrasonography, but there was no vesicoureteral reflux. Lumbosacral magnetic resonance (MR) showed posterior disc bulging at L4-5. Serum sodium and chloride levels were normal, but mild hypokalemia was overlooked initially. During follow-up, hypokalemic hypochloremic metabolic alkalosis developed, with high urinary chloride and potassium excretion (52 and 43 mEq/L, respectively). The patient, with renal salt loss, was thought to have classic Bartter syndrome due to absence of nephrocalcinosis, presence of persistent hypercalciuria and sensorineural deafness, and presence of relatively mild clinical and laboratory findings, except polyuria initially. The child was treated with indomethacin, spironolactone, and oral potassium in addition to growth hormone (GH). During treatment, he had considerable increase in weight and height compared with the period of GH...Continue Reading

References

Jun 1, 1992·The American Journal of the Medical Sciences·R H Ruvalcaba, F E Martinez
Jan 1, 1985·The American Journal of the Medical Sciences·S L BlethenJ C Jennette
Jul 9, 1998·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·J Rodríguez-Soriano
Sep 7, 2000·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·I H SuH Trachtman
Jan 10, 2002·The American Journal of the Medical Sciences·A J Shaer
Mar 15, 2002·The American Journal of Medicine·Melanie PetersHannsjörg W Seyberth
Jun 15, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Willem Proesmans
Jun 21, 2006·Nephron. Physiology·Robert Kleta, Detlef Bockenhauer
Sep 7, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Coral HanevoldRory Dalton
Dec 23, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Alberto BettinelliSilvana Tedeschi
Aug 13, 2008·Nature Clinical Practice. Nephrology·Hannsjörg W Seyberth
Oct 3, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Hajime YamazakiFumitake Gejyo

❮ Previous
Next ❯

Citations

Jan 19, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Miriam R BerryFiona E Karet Frankl
Jan 1, 2014·Journal of Medical Case Reports·Masanori AdachiYumi Asakura
Sep 21, 2011·European Journal of Pediatrics·Takayuki OkamotoSatoshi Sasaki
Mar 2, 2011·Korean journal of pediatrics·Se Eun LeeHae Il Cheong
Nov 6, 2018·Pediatrics International : Official Journal of the Japan Pediatric Society·Ilaria BrambillaGian Luigi Marseglia
Mar 8, 2019·Journal of Pediatric Endocrinology & Metabolism : JPEM·Inna Spector-CohenRephael Halevy
Apr 7, 2017·Journal of the American Society of Nephrology : JASN·Elsa SeysRosa Vargas-Poussou
Mar 1, 2013·Annals of Pediatric Endocrinology & Metabolism·Se Ra MinSung Yeon Ahn
Jul 4, 2020·American Journal of Medical Genetics. Part a·Debra R CountsCarole A Samango-Sprouse
Aug 15, 2019·BMC Medical Genetics·Binlu ZhuHongkun Jiang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.

Related Papers

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Mithat BuyukcelikAyse Balat
Indian Pediatrics
P Saravana KumarM Vijayakumar
Indian Journal of Endocrinology and Metabolism
Soumya PatraDebanjali Sarkar
La Pediatria medica e chirurgica : Medical and surgical pediatrics
M DemiM Mastella
Saudi Medical Journal
Nadia M Al-Hamad, Amal A Al-Eisa
© 2021 Meta ULC. All rights reserved