A patient with bronchial asthma in whom eosinophilic bronchitis and bronchiolitis developed during treatment

Allergology International : Official Journal of the Japanese Society of Allergology
Yasutsugu FukushimaTakeshi Fukuda

Abstract

A 56-year-old woman was referred to our hospital because of dyspnea, wheezing, and a productive cough. Eight years before presentation, bronchial asthma was diagnosed and the patient received inhaled corticosteroids plus antiasthmatic agents (a long-acting inhaled beta2-agonist, leukotriene modifiers, and theophylline). Chest radiography showed small diffuse nodular shadows, and a computed tomographic scan showed thickening of the bronchi and bronchioles, with diffuse centrilobular nodules in both lung fields. A blood test and microscopic examination of the bronchoalveolar fluid revealed marked eosinophilia. Transbronchial lung biopsy and transbronchial biopsy showed eosinophilic bronchitis and bronchiolitis. After treatment with oral prednisolone (40 mg daily) and inhaled corticosteroids, the symptoms, blood eosinophilia, and radiographic findings improved. Recently, several similar cases of eosinophilic bronchiolitis have been reported. Studies of further cases and elucidation of the pathophysiology of eosinophilic bronchiolitis are necessary to establish a concept for this disease and to determine whether it should be classified as a subtype of bronchial asthma or as a distinct entity.

References

Jul 1, 1997·The Journal of Allergy and Clinical Immunology·Q HamidJ C Hogg
Jun 21, 2001·Respiration; International Review of Thoracic Diseases·N TakayanagiT V Colby
Jan 30, 2009·Chronic Respiratory Disease·G W RodwayJ M Sethi

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Citations

Apr 22, 2014·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Li-Hui WangJiu-Yao Wang
Mar 3, 2011·Allergology International : Official Journal of the Japanese Society of Allergology·Hirofumi KiyokawaMichiaki Mishima
Aug 16, 2016·Clinics in Chest Medicine·Vincent Cottin
Sep 16, 2017·Journal of Thoracic Imaging·Haruka SatoJunichi Kadota

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