A patient with Glanzmann's thrombasthenia for emergent abdominal surgery.

Anesthesia and Analgesia
Halil Ibrahim UzunlarNesrin Erciyes

Abstract

Glanzmann's thrombasthenia is a rare autosomal recessive disease characterized by potentially major mucocutaneous complications and nose bleeds. It is considered hazardous for these surgical patients to conceive, with a high risk of urgent surgery. The treatment of bleeding or prevention of hemorrhage for surgery or invasive procedures is based on platelet transfusion. However, platelet transfusions may be responsible for the development of alloimmunization, with a high risk of future platelet refractoriness. We report a surgical case of Glanzmann's thrombasthenia complicated by nasopharyngeal bleeding and managed with platelet transfusions, recombinant activated factor VII, and postoperative airway management in the intensive care unit.

References

Jan 1, 1994·International Anesthesiology Clinics·C E Orlikowski, D A Rocke
May 1, 1996·The Journal of Emergency Medicine·S A Vuckovic
Dec 5, 2000·British Journal of Anaesthesia·V J Martlew
Sep 6, 2002·Pathophysiology of Haemostasis and Thrombosis·Elisabeth Erhardtsen

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Citations

May 6, 2005·Revista de enfermería·Melissa Mercadal, Patrica Martí
Sep 6, 2012·Southern Medical Journal·Lori GoodingJoseph B Zwischenberger
Oct 30, 2010·Neurologia Medico-chirurgica·Hitoshi YamahataKazunori Arita
Feb 26, 2010·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Christian DepnerDaniel Oertli
Jun 21, 2014·Haemophilia : the Official Journal of the World Federation of Hemophilia·M RajpurkarD L Cooper
Jun 9, 2016·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Abhijeet GanapuleAuro Viswabandya

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