A patient with hypereosinophilic syndrome that manifested with acquired hemophilia and elevated IgG4: a case report.

Journal of Medical Case Reports
Yoshiro NagaoHiromasa Harada

Abstract

Hypereosinophilic syndrome is defined as a prolonged state (more than six months) of eosinophilia (greater than 1500 cells/μL), without an apparent etiology and with end-organ damage. Hypereosinophilic syndrome can cause coagulation abnormalities. Among hypereosinophilic syndrome types, the lymphocytic variant (lymphocytic hypereosinophilic syndrome) is derived from a monoclonal proliferation of T lymphocytes. Here, we describe the case of a patient with lymphocytic hypereosinophilic syndrome who presented with a coagulation abnormality. To the best of our knowledge, this is the first such report including a detailed clinical picture and temporal cytokine profile. A 77-year-old Japanese man presented to our facility with massive hematuria and hypereosinophilia (greater than 2600 cells/μl). His eosinophilia first appeared five years earlier when he developed femoral artery occlusion. He manifested with multiple hematomas and prolonged activated partial thromboplastin time. His IgG4 level was remarkably elevated (greater than 2000 mg/dL). Polymerase chain reaction tests of peripheral blood and bone marrow identified lymphocytic hypereosinophilic syndrome. His prolonged activated partial thromboplastin time was found to be due to ...Continue Reading

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Citations

Dec 10, 2014·Diagnostic Pathology·Takashi KarashimaTaro Shuin
Dec 23, 2016·European Journal of Haematology·Mollie N CarruthersLuke Y C Chen
Jan 21, 2017·Experimental and Therapeutic Medicine·Xiaoyan LiJianying Xu
Feb 20, 2018·Experimental and Therapeutic Medicine·Can ChenShenxian Qian
Mar 28, 2018·International Journal of Hematology·Taisuke NarazakiYoshihiro Ogawa
Nov 1, 2015·CEN Case Reports·Hiroki AdachiHitoshi Yokoyama

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Methods Mentioned

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