A Patient with Necrotizing Vasculitis Related to Sarcoidosis, which was Diagnosed via Immunohistochemical Methods Using P. Acnes-Specific Monoclonal Antibodies

Internal Medicine
Seiji NodaMakoto Soejima

Abstract

Propionibacterium acnes (P. acnes) is a commensal bacterium indigenous to the skin. Previous reports have suggested that infection with P. acnes causes sarcoidosis, a systemic granulomatous disease. We present the case of a 63-year-old woman who developed subcutaneous nodules. A skin biopsy revealed necrotizing vasculitis and noncaseating granulomas, which are characteristic of sarcoidosis. Immunohistostaining revealed a P. acnes skin infection, which led to the diagnosis of sarcoidosis. Minocycline treatment resolved the infection and improved the patient's symptoms. We herein report a case in which immunohistochemistry was useful in the diagnosis of sarcoidosis.

References

Dec 1, 1995·Clinical and Experimental Immunology·M KloppenburgF C Breedveld
Jun 27, 2008·Drugs·Christy B Doherty, Ted Rosen
Oct 28, 2009·Disease-a-month : DM·Angeline Lazarus
May 19, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Mariko NegiYoshinobu Eishi
Jul 14, 2012·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Tetsuro SekineShinichiro Kumita
Jun 21, 2013·JAMA Dermatology·Talora Steen, Joseph C English
Jun 26, 2013·Respiratory Investigation·Yoshinobu Eishi
Oct 15, 2014·International Journal of Dermatology·Eleonora RuoccoVincenzo Ruocco
Oct 1, 2015·Journal of the European Academy of Dermatology and Venereology : JEADV·K T AmberM Hertl
Dec 27, 2018·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Tarun DaliaJason Springer
Jan 11, 2019·Internal Medicine·Takuma IsshikiSakae Homma

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Citations

Apr 4, 2021·Journal of Clinical Medicine·Tetsuo YamaguchiYoshinobu Eishi

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Methods Mentioned

BETA
ESR
X-ray

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