PMID: 16637146Apr 28, 2006Paper

A PBTK/TD modeling-based approach can assess arsenic bioaccumulation in farmed tilapia (Oreochromis mossambicus) and human health risks

Integrated Environmental Assessment and Management
Min-Pei LingBo-Ching Chen

Abstract

A biologically based risk-assessment model of arsenic (As) exposure evaluated farmed tilapia (Orechromis mossambicus) and human health during tilapia consumption in an area of southwestern Taiwan where blackfoot disease (BFD) occurs. The risk assessment addressed exposures to city residents who lived in Taipei, Taichung, and Kaohsiung, as well as subsistence fishers living in the BFD area who consumed tilapia. The models implemented included a physiologically based toxicokinetic and toxicodynamic (PBTK/TD) model to account for As exposure and dose-response profiles in tilapia and a human health exposure/risk model that accounts for target lifetime risk (TR) and hazard quotient (HQ) for humans consuming farmed tilapia. Results demonstrated that 90th percentiles of TR ranged from 1.53 x 10(-8) to 1.62 x 10(-6) for city residents with farmed tilapia consumption rates of 0.41 to 1.37 g/d. The 90th percentiles ranged from 2.07 x 10(-6) to 7.89 x 10(-5) for subsistence fishers in the BFD area with farmed tilapia consumption rates of 16.80 to 59.15 g/d. All predicted 90th percentiles of HQ were less than 1 for city residents and subsistence fishers in the BFD area, indicating small contributions from farmed tilapia consumption. Critic...Continue Reading

References

Jul 1, 1997·Toxicology and Applied Pharmacology·R Abbas, W L Hayton
Oct 20, 1998·Archives of Environmental Contamination and Toxicology·B HanR J Tseng
Apr 15, 2000·Risk Analysis : an Official Publication of the Society for Risk Analysis·H J ClewellA M Shipp
Sep 10, 2003·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yung-Kay HuangYu-Mei Hsueh
Oct 22, 2003·Environmental Pollution·Chung-Min Liao, Min-Pei Ling
Nov 5, 2003·Environmental Science & Technology·Shih-Chun Candice LungYu-Pin Bau

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Citations

Feb 26, 2008·Bulletin of Environmental Contamination and Toxicology·B-C Chen, C-M Liao
May 20, 2009·Bulletin of Environmental Contamination and Toxicology·M-P Ling, C-M Liao
Jan 24, 2012·The Science of the Total Environment·Wei-Yu ChenChung-Min Liao
Sep 24, 2010·Journal of Environmental Monitoring : JEM·Roman Ashauer, Beate I Escher
Feb 14, 2019·Environmental Toxicology and Chemistry·Ian Edhlund, Cindy Lee
Sep 2, 2011·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Sandeep KarHsueh-Yu Lu
Feb 9, 2020·Biomolecules·Yuxin HuYuanyuan Xu
Jan 28, 2021·The Science of the Total Environment·Kai-Wei JuangBo-Ching Chen

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