A peek inside the neurosecretory brain through Orthopedia lenses

Developmental Dynamics : an Official Publication of the American Association of Anatomists
Luca Del GiaccoPaolo Sordino

Abstract

The wealth of expression and functional data presented in this overview discloses the homeogene Orthopedia (Otp) as critical for the development of the hypothalamic neuroendocrine system of vertebrates. Specifically, the results depict the up-to-date portrait of the regulation and functions of Otp. The development of neuroendocrine nuclei relies on Otp from fish to mammals, as demonstrated for several peptide and hormone releasing neurons. Additionally, the activity of Otp is essential for the induction of the dopaminergic phenotype in the hypothalamus of vertebrates. Recent insights into the pathways required for Otp regulation have revealed the implication of the main extracellular signals acting during hypothalamic development. Alterations in these pathways are involved in several neuronal disorders, and the resultant downstream misregulation of Otp might impair the development of the hypothalamus, and be therefore responsible for the neuroendocrine dysfunctions that typify these diseases.

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Citations

Jun 19, 2013·Orphanet Journal of Rare Diseases·Nadia A AkawiLihadh Al-Gazali
Nov 10, 2012·Journal of Chemical Neuroanatomy·Caio MaximinoAnderson Manoel Herculano
Oct 30, 2012·General and Comparative Endocrinology·Dinushan Nesan, Mathilakath M Vijayan
Sep 12, 2012·The Journal of Comparative Neurology·Laura DomínguezNerea Moreno
Mar 11, 2011·Annals of the New York Academy of Sciences·Yossy MachlufGil Levkowitz
Oct 15, 2013·The Journal of Comparative Neurology·Laura DomínguezNerea Moreno
Jan 12, 2010·Neurobiology of Aging·Ilaria GuellaStefano Goldwurm
May 30, 2020·Genesis : the Journal of Genetics and Development·Yu HuZhonghua Lu
Mar 30, 2018·Frontiers in Neuroanatomy·Gabriel N Santos-DuránEva Candal
Dec 10, 2016·Frontiers in Neuroanatomy·Gabriel N Santos-DuránEva Candal
Apr 7, 2021·Molecules and Cells·Jangham JungMyungchull Rhee

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