PMID: 9650171Jul 3, 1998Paper

A pencil-beam photon dose algorithm for stereotactic radiosurgery using a miniature multileaf collimator

Medical Physics
L DongKenneth R Hogstrom

Abstract

A computer-controlled miniature multileaf collimator (MMLC) with 4 mm leaf width and a maximum field size of 6 cm X 6 cm has been designed as a tertiary beam-shaping device for linac-based stereotactic radiosurgery. The purpose of this study is to develop an accurate and efficient dose calculation model for use with the MMLC. A pencil-beam based algorithm using a sum of three Gaussian kernels was developed to model the off-axis ratio of MMLC fields. Because the kernel integration over a rectangular field can be solved in closed form, dose to any point from an arbitrary MMLC field can be calculated efficiently by summing dose contribution from a set of rectangular apertures and transmission blocks that model individual leaf openings or leaf transmissions. The model uses an effective rectangular field and equivalent square method for determination of depth dose and dose output. Results showed that the calculated percentage depth dose was within 1% and output factor was within 1.5% of measured data. The parameters of the pencil beam kernels were extracted by fitting measured off-axis profiles for a few field sizes at a few depths. The accuracy of the calculated off-axis ratio was tested by comparison with measured data for a numbe...Continue Reading

References

Nov 1, 1992·Medical Physics·P B Dunscombe, J M Nieminen
Nov 1, 1989·Medical Physics·A S ShiuK R Hogstrom
Sep 1, 1994·Medical Physics·E L ChaneyT A Gabriel
Jan 15, 1993·International Journal of Radiation Oncology, Biology, Physics·J M GalvinB Lally
Jul 1, 1996·Medical Physics·C W Cheng, I J Das
Feb 1, 1997·International Journal of Radiation Oncology, Biology, Physics·A S ShiuM H Maor
Feb 1, 1994·Physics in Medicine and Biology·T J Jordan, P C Williams

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Citations

Jun 9, 2007·Medical Physics·Friedlieb LorenzPiotr Zygmanski
Jan 20, 2005·Zeitschrift für medizinische Physik·Pierre-Alain TercierJean-François Valley
Aug 31, 2002·Medical Physics·Karl OttoCalvin Huntzinger
May 2, 2008·Journal of Applied Clinical Medical Physics·Jeong-Woo LeeTae-Suk Suh
Aug 8, 2002·Physics in Medicine and Biology·Thomas BortfeldSteve B Jiang
Apr 17, 2009·Physics in Medicine and Biology·Armand DjouguelaBjörn Poppe
Dec 29, 2000·Medical Physics·T BortfeldS Nill

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