PMID: 7581271Jun 1, 1995Paper

A peptide, ALTTE, within the fimbrial subunit protein from Porphyromonas gingivalis, induces production of interleukin 6, gene expression and protein phosphorylation in human peripheral blood mononuclear cells

FEMS Immunology and Medical Microbiology
T Ogawa, H Uchida

Abstract

Porphyromonas gingivalis 381 fimbriae and a synthetic peptide composed of residues 69-73 (ALTTE) of the fimbrial subunit protein, FP381(69-73), function in the induction of interleukin 6 (IL-6) production, IL-6 mRNA expression, and tyrosine and serine/threonine phosphorylation of several proteins in human peripheral blood mononuclear cells (PBMC). Herbimycin A and H-7, inhibitors of tyrosine kinases and protein kinase C (PKC), markedly inhibited IL-6 production, gene expression, and tyrosine and serine/threonine phosphorylation of proteins. An inactive analog of synthetic peptide replaced alanine to glycine at position 69 in FP381(69-73), GLTTE, exhibited an antagonistic effect on the IL-6 production induced by the fimbriae. These results suggest that the peptide ALTTE functions as an agent in inflammatory reactions and immune responses in the inflamed gingival and periodontal tissues, in which the participation of protein phosphorylation by tyrosine kinases and PKC in signal transduction may be considered.

References

Dec 1, 1992·Oral Microbiology and Immunology·K WatanabeT Umemoto
Nov 14, 1991·Biochemical and Biophysical Research Communications·T OgawaS Hamada
May 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·S L WeinsteinA L DeFranco
Sep 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·A J RossomandoT W Sturgill
Jan 1, 1988·Annual Review of Immunology·T Kishimoto, T Hirano
Jan 1, 1968·Scandinavian Journal of Clinical and Laboratory Investigation·C E Mogensen
Nov 30, 1984·Biochemical and Biophysical Research Communications·S Kawamoto, H Hidaka
Jan 1, 1980·Methods in Enzymology·A M Maxam, W Gilbert
Apr 1, 1993·Trends in Biochemical Sciences·E Nishida, Y Gotoh

❮ Previous
Next ❯

Citations

Sep 29, 2000·Microbes and Infection·P J Baker
Aug 12, 2006·Journal of Clinical Periodontology·Lone FornerPalle Holmstrup
Jan 26, 2011·Journal of Clinical Periodontology·Fei YuWeimin Chen
May 10, 2001·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·H Wu, P M Fives-Taylor
Aug 18, 2010·Periodontology 2000·John J Taylor
Sep 5, 2002·FEMS Immunology and Medical Microbiology·Pamela J BakerDerry C Roopenian
May 25, 2007·Glycobiology·Alexandre P RogerioLúcia H Faccioli
Mar 13, 2019·Journal of Leukocyte Biology·Samreen SadafMadhu Dikshit
Aug 23, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ya Chee LimSheba R David
Jun 18, 2017·Biological Chemistry·Mili JainAnil Kumar Tripathi
Sep 26, 2001·Acta Odontologica Scandinavica·P J BakerD C Roopenian
Mar 5, 2002·Clinical and Diagnostic Laboratory Immunology·George HajishengallisRobert J Genco
Jan 13, 2001·Oral Microbiology and Immunology·P J BakerD C Roopenian
Jun 22, 1999·Infection and Immunity·H Xie, R J Lamont
May 1, 1999·Biochemical and Biophysical Research Communications·A SharmaR J Genco
Dec 5, 1998·Microbiology and Molecular Biology Reviews : MMBR·R J Lamont, H F Jenkinson
Jan 1, 1997·Infection and Immunity·A WeinbergR J Lamont

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Indian Journal of Dental Research : Official Publication of Indian Society for Dental Research
Ali M Tavana
European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies
A MarusićS Jonjić
Journal of Clinical Periodontology
T Pilot, H Miyazaki
© 2021 Meta ULC. All rights reserved