A peptide nucleic acid-neamine conjugate that targets and cleaves HIV-1 TAR RNA inhibits viral replication

Journal of Medicinal Chemistry
Emmanuel RiguetJean-Luc Décout

Abstract

The neamine part of the aminoglycoside antibiotic neomycin B was conjugated to a 16 mer peptide nucleic acid (PNA) targeting HIV-1 TAR RNA. Attachment of the neamine core allows cellular uptake of the PNA and results in potent inhibition of HIV-1 replication. The polycationic neamine moiety imparts greater solubility to the PNA and also confers a unique RNA cleavage property to the conjugate which is specific to its target site and functional at physiological concentrations of Mg(2+). These properties suggest a potential therapeutic application for this class of compounds.

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Citations

Oct 3, 2013·Journal of Medicinal Chemistry·Louis ZimmermannJean-Luc Décout
Oct 17, 2013·Chemical Research in Toxicology·Maralise Perigolo de OliveiraJean-Luc Décout
Jan 9, 2010·Annual Review of Pharmacology and Toxicology·C Frank Bennett, Eric E Swayze
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Jul 8, 2008·Chembiochem : a European Journal of Chemical Biology·Jesus RazkinLars Baltzer
Dec 17, 2005·Organic & Biomolecular Chemistry·Teija Niittymäki, Harri Lönnberg
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